Proinflammatory and immunoregulatory functions of interleukin-12. (Q41722212)

8 October 2017

1 reference

title

Proinflammatory and immunoregulatory functions of interleukin-12. (English)

1 reference

8 October 2017

Trinchieri G

1

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8 October 2017

1 January 1998

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International Reviews of Immunology

8 October 2017

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8 October 2017

16

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8 October 2017

365-396

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8 October 2017

3-4

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Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

8 October 2017

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin-12 and its role in the generation of TH1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Mapping of genes controlling Leishmania major infection in CXS recombinant inbred mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

IL12 receptors and receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Biological function and distribution of human interleukin-12 receptor beta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Impaired interleukin 12 production in human immunodeficiency virus-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Preferential expression of interleukin-12 or interleukin-4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Identification and induction of human keratinocyte-derived IL-12

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Administration of recombinant interleukin-12 to mice suppresses hematopoiesis in the bone marrow but enhances hematopoiesis in the spleen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Multiple effects on peripheral hematology following administration of recombinant human interleukin 12 to nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin-12 and malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Regulation of human cytolytic lymphocyte responses by interleukin-12

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Differential effects of IL12 and IL2 on expression and function of cellular adhesion molecules on purified human natural killer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Differential effects of interleukin-12 on the development of naive mouse CD4+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Acute induction and priming for cytokine production in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin-12 stimulates B cell growth by inducing IFN-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

The effects of IL12 on B-cell subset function.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

The adjuvant effect of interleukin-12 in a vaccine against Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

IL12 in Candida albicans infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Role of IL12 in HIV disease/AIDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Priming for high interferon-gamma production induced by interleukin-12 in both CD4+ and CD8+ T cell clones from HIV-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

In vitro restoration of T cell immune function in human immunodeficiency virus-positive persons: effects of interleukin (IL)-12 and anti-IL-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin-12 and its role in cutaneous sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Mechanism of suppression of cell-mediated immunity by measles virus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Antitumor and antimetastatic activity of interleukin 12 against murine tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Inhibition of angiogenesis in vivo by interleukin 12.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

The role of IL-12 in the induction of organ-specific autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Effect of anti-interleukin 12 treatment on murine lyme borreliosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Recombinant interleukin-12 enhances resistance of mice to Listeria monocytogenes infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Recombinant interleukin 12 cures mice infected with Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Interleukin 12 induction of interferon gamma-dependent protection against malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

Infection with Leishmania major induces interleukin-12 production in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830189809043002

10.3109/08830189809043002

21 January 2018

Identifiers

DOI

1 reference

8 October 2017

1 reference

PubMed ID

9505196