CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses? (Q41729825)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9523116%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

review article

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title

CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9523116%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1

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10 November 2019

author name string

Zamoyska R

series ordinal

1

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8 October 2017

language of work or name

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1 February 1998

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9523116%20AND%20SRC:MED&resulttype=core&format=json

Current Opinion in Immunology

10 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9523116%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

volume

10

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10 November 2019

issue

1

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10 November 2019

page(s)

82-87

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T Cell Subsets and the Recognition of MHC Class

10 November 2019

cites work

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Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2-terminal domains

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Dimeric association and segmental variability in the structure of human CD4

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Ligand-specific oligomerization of T-cell receptor molecules

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The two membrane proximal domains of CD4 interact with the T cell receptor

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Molecular biology and function of CD4 and CD8

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Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution

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Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2

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Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain

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Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.

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CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity

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CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

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Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

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CD8 is needed for development of cytotoxic T cells but not helper T cells

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7 January 2021

Helper T-cell development in the absence of CD4-p56 Ick association

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The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes

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The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the T cell receptor (TCR) and influences negative selection in TCR-transgenic mice

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7 January 2021

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7 January 2021

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7 January 2021

An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex

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7 January 2021

Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

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7 January 2021

Co-capping studies reveal CD8/TCR interactions after capping CD8β polypeptides and intracellular associations of CD8 with p56lck

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7 January 2021

10.1016/S0952-7915(98)80036-8

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9523116%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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