Herpes simplex virus 2 ICP34.5 confers neurovirulence by regulating the type I interferon response (Q41732899)

8 October 2017

title

Herpes simplex virus 2 ICP34.5 confers neurovirulence by regulating the type I interferon response (English)

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8 October 2017

Katie L Davis

1

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8 October 2017

Maria Korom

series ordinal

2

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8 October 2017

Lynda A Morrison

series ordinal

3

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8 October 2017

language of work or name

English

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publication date

17 September 2014

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8 October 2017

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8 October 2017

volume

468-470

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8 October 2017

page(s)

330-339

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Val193 and Phe195 of the gamma 1 34.5 protein of herpes simplex virus 1 are required for viral resistance to interferon-alpha/beta

8 October 2017

cites work

1 reference

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AlaArg motif in the carboxyl terminus of the gamma(1)34.5 protein of herpes simplex virus type 1 is required for the formation of a high-molecular-weight complex that dephosphorylates eIF-2alpha

7 January 2021

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7 January 2021

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Herpes simplex virus 2 virion host shutoff protein interferes with type I interferon production and responsiveness

7 January 2021

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Herpes simplex virus type 2-mediated disease is reduced in mice lacking RNase L

7 January 2021

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7 January 2021

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The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-

7 January 2021

1 reference

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The gamma134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells

7 January 2021

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Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2.

7 January 2021

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Neonatal herpes: what have we learned

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Selective ablation of virion host shutoff protein RNase activity attenuates herpes simplex virus 2 in mice

7 January 2021

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7 January 2021

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Up to four distinct polypeptides are produced from the γ34.5 open reading frame of herpes simplex virus 2

7 January 2021

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Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo

7 January 2021

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Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene

7 January 2021

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ICP34.5 protein of herpes simplex virus facilitates the initiation of protein translation by bridging eukaryotic initiation factor 2alpha (eIF2alpha) and protein phosphatase 1

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Herpes simplex virus type 2 virion host shutoff protein regulates alpha/beta interferon but not adaptive immune responses during primary infection in vivo

7 January 2021

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HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein

7 January 2021

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Intravaginal administration of herpes simplex virus type 2 to mice leads to infection of several neural and extraneural sites

7 January 2021

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7 January 2021

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A variant of herpes simplex virus type 2 strain HG52 with a 1.5 kb deletion in RL between 0 to 0.02 and 0.81 to 0.83 map units is non-neurovirulent for mice

7 January 2021

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The herpes simplex virus type 2 (HG52) variant JH2604 has a 1488 bp deletion which eliminates neurovirulence in mice

7 January 2021

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Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway

7 January 2021

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An acutely and latently expressed herpes simplex virus 2 viral microRNA inhibits expression of ICP34.5, a viral neurovirulence factor

7 January 2021

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Herpes simplex virus 2 expresses a novel form of ICP34.5, a major viral neurovirulence factor, through regulated alternative splicing

7 January 2021

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Novel less-abundant viral microRNAs encoded by herpes simplex virus 2 latency-associated transcript and their roles in regulating ICP34.5 and ICP0 mRNAs.

7 January 2021

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The herpes simplex virus type 1 strain 17+ gamma 34.5 deletion mutant 1716 is avirulent in SCID mice

7 January 2021

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Dephosphorylation of eIF2alpha mediated by the gamma134.5 protein of herpes simplex virus 1 facilitates viral neuroinvasion

7 January 2021

1 reference

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Control of TANK-binding kinase 1-mediated signaling by the gamma(1)34.5 protein of herpes simplex virus 1

7 January 2021

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Increased eIF2alpha phosphorylation attenuates replication of herpes simplex virus 2 vhs mutants in mouse embryonic fibroblasts and correlates with reduced accumulation of the PKR antagonist ICP34.5.

7 January 2021

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Oncogenic transformation of hamster cells after exposure to herpes simplex virus type 2.

7 January 2021

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.VIROL.2014.08.015

1 reference

8 October 2017

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