Drug targeting via retrometabolic approaches (Q41735596)

8 October 2017

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title

Drug targeting via retrometabolic approaches (English)

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8 October 2017

2

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8 October 2017

Bodor N

1

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8 October 2017

1 October 1997

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Pharmacology & Therapeutics

8 October 2017

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8 October 2017

76

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8 October 2017

1-3

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8 October 2017

1-27

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The metabolism in vivo of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in the chick by embryonic injection and dietary ingestion.

8 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

pH-metric log P. 6. Effects of sodium, potassium, and N-CH3-D-glucamine on the octanol-water partitioning of prostaglandins E1 and E2.

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Designing safer drugs based on the soft drug approach

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Soft drugs: principles and methods for the design of safe drugs

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Redox drug delivery systems for targeting drugs to the brain

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Problems of delivery of drugs to the brain

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Improved delivery through biological membranes. 11. A redox chemical drug-delivery system and its use for brain-specific delivery of phenylethylamine

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

An extended version of a novel method for the estimation of partition coefficients.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

A new method for the estimation of the aqueous solubility of organic compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Soft drugs. 2. Soft alkylating compounds as potential antitumor agents

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Site- and stereospecific ocular drug delivery by sequential enzymatic bioactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Soft drugs V: Thiazolidine-type derivatives of progesterone and testosterone

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Formation of adrenaline in the iris-ciliary body from adrenalone diesters

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Soft drugs. 1. Labile quaternary ammonium salts as soft antimicrobials

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Soft drugs. 3. A new class of anticholinergic agents.

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Site-specific, sustained release of drugs to the brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Soft Drugs VI. The Application of the Inactive Metabolite Approach for Design of Soft β-Blockers1?2

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Soft drugs. 7. Soft .beta.-blockers for systemic and ophthalmic use

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Improved delivery through biological membranes. 26. Design, synthesis, and pharmacological activity of a novel chemical delivery system for beta-adrenergic blocking agents

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

A comparison of intraocular pressure elevating activity of loteprednol etabonate and dexamethasone in rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

A strategy for delivering peptides into the central nervous system by sequential metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Ocular-specific delivery of timolol by sequential bioactivation of its oxime and methoxime analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Improved Delivery Through Biological Membranes. XXIV. Synthesis, in Vitro Studies, and in Vivo Characterization of Brain-Specific and Sustained Progestin Delivery Systems.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Improved delivery through biological membranes. 32. Synthesis and biological activity of brain-targeted delivery systems for various estradiol derivatives.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Peptidases, peptides, and the mammalian blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Regioselective O-alkylation of cortienic acid and synthesis of a new class of glucocorticoids containing a 17 alpha-alkoxy, a 17 alpha-(1'-alkoxyethyloxy), a 17 alpha-alkoxymethyloxy, or a 17 alpha-methylthiomethyloxy function

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Soft drugs--10. Blanching activity and receptor binding affinity of a new type of glucocorticoid: loteprednol etabonate

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Determined of bufuralol and its metabolites in plasma by mass fragmentography and by gas chromatography with electron capture detection

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Site-specific drug delivery

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Acute toxicity of pesticides

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Potential and limitations of drug targeting: an overview

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

A pro-drug of zidovudine with enhanced efficacy against human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Intrinsic sympathomimetic activity of β-adrenoceptor blocking drugs at cardiac and vascular β-adrenoceptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Short acting soft mydriatics

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

The kappa-opioid receptor expressed on the mouse lymphoma cell line R1.1 contains a sulfhydryl group at the binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

N‐halo derivatives III: Stabilization of nitrogen‐chlorine bond in N‐chloroamino acid derivatives

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

N-Halo derivatives IV: Synthesis of low chlorine potential soft N-chloramine systems

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Design and synthesis of an opioid receptor probe: mode of binding of S-activated (-)-6 beta-sulfhydryldihydromorphine with the SH group in the mu-opioid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Carcinogenicity of DDT (dichlorodiphenyl trichloroethane) in pure inbred Swiss mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Synthesis and evaluation of brain-targeted chemical delivery systems for the neurotrophomodulator 4-methylcatechol

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Soft drugs--XVI. Design, evaluation and transdermal penetration of novel soft anticholinergics based on methatropine

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Soft drugs 15: mydriatic activity and transcorneal penetration of phenylsuccinic soft analogs of methscopolamine as short acting mydriatics

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Beta-adrenoceptor activity of the stereoisomers of the bufuralol alcohol and ketone metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Drug targeting systems for antiviral agents: options and limitations

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

A dihydropyridine carrier system for sustained delivery of 2',3'-dideoxynucleosides to the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Minimal cardiac electrophysiological activity of alprenoxime, a site-activated ocular beta-blocker, in dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Chemical delivery systems for some penicillinase-resistant semisynthetic penicillins.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Brain-specific chemical delivery systems for beta-lactam antibiotics. Synthesis and properties of some dihydropyridine and dihydroiosquinoline derivatives of benzylpenicillin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Ocular delivery of the beta-adrenergic antagonist alprenolol by sequential bioactivation of its methoxime analogue.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Drug delivery systems. 1. site-specific drug delivery using liposomes as carriers

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Potential treatment of herpes simplex virus encephalitis by brain-specific delivery of trifluorothymidine using a dihydropyridine in equilibrium pyridinium salt type redox delivery system

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

In vitro evaluation of a controlled-release site-specific diisovaleryl tert-butalone chemical delivery system for the eye

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https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Design, synthesis, and pharmacokinetic evaluation of a chemical delivery system for drug targeting to lung tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Studies on inhibition of mu and delta opioid receptor binding by dithiothreitol and N-ethylmaleimide. His223 is critical for mu opioid receptor binding and inactivation by N-ethylmaleimide

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

AIDS dementia: synthesis and properties of a derivative of 3'-azido-3'-deoxythymidine (AZT) that may become 'locked' in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

Soft drugs. XX. Design, synthesis, and evaluation of ultra-short acting beta-blockers

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2897%2900098-3

7 January 2021

10.1016/S0163-7258(97)00098-3

Identifiers

DOI

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8 October 2017

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PubMed ID

9535166