The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands (Q41738022)

8 October 2017

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title

The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands (English)

1 reference

8 October 2017

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E Tzahar

1

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PubMed ID

9540810

8 October 2017

Y Yarden

series ordinal

2

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8 October 2017

1 February 1998

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Biochimica et Biophysica Acta

8 October 2017

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8 October 2017

1377

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8 October 2017

1

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8 October 2017

M25-37

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The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

8 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Amplification of a novel v-erbB-related gene in a human mammary carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Molecular and clinical aspects of the Neu/ErbB-2 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Experimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Biochemical analysis of the ligand for the neu oncogenic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Identification of heregulin, a specific activator of p185erbB2

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

NDF/heregulin stimulates the phosphorylation of Her3/erbB3

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Ligands for ErbB-family receptors encoded by a neuregulin-like gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Overexpression of the c-erbB-2 oncoprotein: why does this occur more frequently in ductal carcinoma in situ than in invasive mammary carcinoma and is this of prognostic significance?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Prognostic significance of her-2/neu expression in breast cancer and its relationship to other prognostic factors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Prognostic value of c-erbB-2 protein expression in human lung adenocarcinoma and squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Response to mitoxantrone in advanced breast cancer: correlation with expression of c-erbB-2 protein and glutathione S-transferases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

The erbB 2 oncogene and chemotherapy: a mini-review

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Targeted inhibition of tumor-cell growth by recombinant heregulin-toxin fusion proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

HER4 expression correlates with cytotoxicity directed by a heregulin-toxin fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that overexpresses the proto-oncogene HER-2/neu

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Tyrphostins. II. Heterocyclic and .alpha.-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Epidermal growth factor-related peptides and their receptors in human malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Prognostic significance of transforming growth factor-alpha in human esophageal carcinoma. Implication for the autocrine proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Structural alterations of the epidermal growth factor receptor gene in human gliomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Type-1 growth factor receptors in pancreatic and gastrointestinal neoplasia.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Vulval development in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Multiple essential functions of neuregulin in development

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

The cellular response to neuregulins is governed by complex interactions of the erbB receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Neu differentiation factor inhibits EGF binding. A model for trans-regulation within the ErbB family of receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

The structural basis for the specificity of epidermal growth factor and heregulin binding

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Bivalence of EGF-like ligands drives the ErbB signaling network

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Neu differentiation factor/neuregulin isoforms activate distinct receptor combinations.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Binding of Neu differentiation factor with the extracellular domain of Her2 and Her3

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Identification of residues of the epidermal growth factor receptor proximal to residue 45 of bound epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Topographic analysis of human epidermal growth factor by monospecific antibodies and synthetic peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Multidomain binding of transforming growth factor alpha to the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Two EGF molecules contribute additively to stabilization of the EGFR dimer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Ligand and p185c-neu density govern receptor interactions and tyrosine kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Molecular aspects of mesenchymal-epithelial interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900032-2

7 January 2021

10.1016/S0304-419X(97)00032-2

Identifiers

DOI

1 reference

8 October 2017

1 reference

PubMed ID

9540810