Antibodies to OX-40 (CD134) can identify and eliminate autoreactive T cells: implications for human autoimmune disease (Q41740874)

8 October 2017

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title

Antibodies to OX-40 (CD134) can identify and eliminate autoreactive T cells: implications for human autoimmune disease (English)

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8 October 2017

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Weinberg AD

1

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8 October 2017

1 February 1998

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Trends in Molecular Medicine

8 October 2017

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8 October 2017

4

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8 October 2017

2

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8 October 2017

76-83

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Homing of T cells to the central nervous system throughout the course of relapsing experimental autoimmune encephalomyelitis in Thy-1 congenic mice

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Myelin basic protein specific T cell lines and clones derived from the CNS of rats with EAE only recognize encephalitogenic epitopes

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OX-40 antibody enhances for autoantigen specific V beta 8.2+ T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitis

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V beta CDR3 motifs associated with BP recognition are enriched in OX-40+ spinal cord T cells of Lewis rats with EAE

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Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts

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CD27: marker and mediator of T-cell activation?

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Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized

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Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3

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Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis

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Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

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Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides

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The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen

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Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers

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Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor

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Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34

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The B7 and CD28 receptor families

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Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

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The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells

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7 January 2021

10.1016/S1357-4310(97)01181-7

Identifiers

DOI

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8 October 2017

1 reference

PubMed ID

9547794