Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase. (Q41774206)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23752511%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase (English)

1 reference

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2 March 2020

main subject

antibiotic resistance

1 reference

1

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2 March 2020

Tanel Tenson

3

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2 March 2020

Finn Kirpekar

5

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2 March 2020

Birte Vester

6

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2 March 2020

author name string

Lykke H Hansen

2

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2 March 2020

Anette Rasmussen

4

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2 March 2020

language of work or name

English

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publication date

10 June 2013

1 reference

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Antimicrobial Agents and Chemotherapy

2 March 2020

published in

1 reference

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2 March 2020

volume

57

1 reference

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2 March 2020

issue

8

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2 March 2020

page(s)

4019-4026

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The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy.

2 March 2020

cites work

1 reference

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The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene

6 June 2018

1 reference

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Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation

6 June 2018

1 reference

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Low fitness cost of the multidrug resistance gene cfr.

6 June 2018

1 reference

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

6 June 2018

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Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance

6 June 2018

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A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

6 June 2018

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RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift

6 June 2018

1 reference

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Evolution of elongation factor G and the origins of mitochondrial and chloroplast forms

6 June 2018

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The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide

6 June 2018

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Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection

6 June 2018

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Parallelization of the MAFFT multiple sequence alignment program

6 June 2018

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6 June 2018

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Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

6 June 2018

1 reference

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Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

6 June 2018

1 reference

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Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719738

The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719738

Identifying modifications in RNA by MALDI mass spectrometry

6 June 2018

1 reference

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S-adenosylmethionine as an oxidant: the radical SAM superfamily

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719738

RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719738

Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719738

The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3719738

Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

6 June 2018

1 reference

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A novel partial modification at C2501 in Escherichia coli 23S ribosomal RNA

6 June 2018

1 reference

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Detection of pseudouridine and other modifications in tRNA by cyanoethylation and MALDI mass spectrometry

6 June 2018

1 reference

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Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

6 June 2018

1 reference

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Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri

6 June 2018

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6 June 2018

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Mutants of Escherichia coli permeable to actinomycin

6 June 2018

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Detection of the staphylococcal multiresistance gene cfr in Macrococcus caseolyticus and Jeotgalicoccus pinnipedialis

6 June 2018

1 reference

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Identification of 5-hydroxycytidine at position 2501 concludes characterization of modified nucleotides in E. coli 23S rRNA.

18 August 2018

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Modifications in Thermus thermophilus 23 S ribosomal RNA are centered in regions of RNA-RNA contact.

18 August 2018

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A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503.

18 August 2018

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Posttranscriptional modification of the central loop of domain V in Escherichia coli 23 S ribosomal RNA.

18 August 2018

1 reference

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Linezolid-resistant clinical isolates of meticillin-resistant coagulase-negative staphylococci and Enterococcus faecium from China

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23752511

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.00448-13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23752511%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23752511%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

PubMed publication ID

23752511

1 reference