Pharmacological activities of TEI-8362, a novel inhibitor of human neutrophil elastase (Q41777507)

9 October 2017

Pharmacological activities of TEI-8362, a novel inhibitor of human neutrophil elastase (English)

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9 October 2017

H Mitsuhashi

1

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9 October 2017

T Nonaka

2

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9 October 2017

I Hamamura

3

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9 October 2017

T Kishimoto

4

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9 October 2017

E Muratani

5

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9 October 2017

K Fujii

6

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9 October 2017

language of work or name

English

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publication date

1 March 1999

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British Journal of Pharmacology

9 October 2017

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9 October 2017

126

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9 October 2017

5

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9 October 2017

1147-1152

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Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesion

9 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

Bronchiectasis--new therapeutic approaches based on pathogenesis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

ONO-5046, a novel inhibitor of human neutrophil elastase

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

Clinical and pathophysiological significance of neutrophil elastase in sputum and the effect of erythromycin in chronic respiratory diseases

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

Biochemical and pharmacological activities of SR 26831, a potent and selective elastase inhibitor

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

Role of neutrophil elastase in allergen-induced lysozyme secretion in the dog trachea

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

Proteinase/proteinase inhibitor imbalance in sputum sol phases from patients with chronic obstructive pulmonary disease. Suggestions for a key role played by antileukoprotease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

Neutrophil elastase stimulates tracheal submucosal gland secretion that is inhibited by ICI 200,355

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

Sensitive substrates for human leukocyte and porcine pancreatic elastase: A study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

Proteases from purulent sputum. Purification and properties of the elastase and chymotrypsin-like enzymes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

Recombinant human secretory leukocyte-protease inhibitor: in vitro properties, and amelioration of human neutrophil elastase-induced emphysema and secretory cell metaplasia in the hamster.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565894

Biochemistry and pharmacology of ICI 200,880, a synthetic peptide inhibitor of human neutrophil elastase

18 August 2018

1 reference

12 December 2020

5-Methyl-4H-3,1-benzoxazin-4-one derivatives: specific inhibitors of human leukocyte elastase

1 reference

12 December 2020

Pharmacology of N-[4-(4-morpholinylcarbonyl)benzoyl]-L-valyl-N- [3,3,4,4,4-pentafluoro-1-(1-methylethyl)-2-oxobutyl]-L-prolinamide (MDL 101,146): a potent orally active inhibitor of human neutrophil elastase

1 reference

12 December 2020

Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular-matrix bound basic fibroblast growth factor

1 reference

12 December 2020

Aerosolized human neutrophil elastase induces airway constriction and hyperresponsiveness with protection by intravenous pretreatment with half-length secretory leukoprotease inhibitor

1 reference

12 December 2020

Potency of truncated secretory leukoprotease inhibitor assessed in acute lung injury models in hamsters

1 reference

12 December 2020

Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor

1 reference

12 December 2020

Evaluation of the internationally standardized method for haemoglobinometry

1 reference

12 December 2020

Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis

1 reference

12 December 2020

A modified bronchoalveolar lavage procedure that allows measurement of lung epithelial lining fluid volume

1 reference

12 December 2020

A comparison of alpha 1-proteinase inhibitor methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone and specific beta-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster

1 reference

12 December 2020

Inhibition of chymotrypsin and pancreatic elastase by 4H-3,1-benzoxazin-4-ones

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0702425

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9 October 2017

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9 October 2017

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