Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2. (Q41792392)

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2 January 2020

title

Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2 (English)

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2 January 2020

1

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2 January 2020

author name string

Min Zhuang

series ordinal

2

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2 January 2020

Olivier Ayrault

series ordinal

3

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2 January 2020

Brenda A Schulman

series ordinal

4

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2 January 2020

language of work or name

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10 February 2008

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Nature Structural & Molecular Biology

2 January 2020

published in

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volume

15

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2 January 2020

page(s)

280-287

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2 January 2020

issue

3

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https://scigraph.springernature.com/pub.10.1038/nsmb.1387

2 January 2020

exact match

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E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer

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Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway

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31 March 2020

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E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

31 March 2020

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Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8

31 March 2020

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Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1

31 March 2020

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31 March 2020

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The Intrinsic Affinity between E2 and the Cys Domain of E1 in Ubiquitin-like Modifications

31 March 2020

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Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes

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Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

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Nedd8-modification of Cul1 is promoted by Roc1 as a Nedd8-E3 ligase and regulates its stability

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

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Optimization of specificity in a cellular protein interaction network by negative selection

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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

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31 March 2020

Identifiers

DOI

10.1038/NSMB.1387

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18264111%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

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