Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity (Q41806994)

From Wikidata

Jump to navigation Jump to search

scientific article published on May 1998

Language	Label	Description	Also known as
English	Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity	scientific article published on May 1998

Statements

scholarly article

1 reference

Europe PubMed Central

12 October 2017

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity (English)

1 reference

Europe PubMed Central

12 October 2017

1 reference

based on heuristic

inferred from title

author name string

G Smith

1

1 reference

Europe PubMed Central

12 October 2017

S Modi

2

1 reference

Europe PubMed Central

12 October 2017

I Pillai

3

1 reference

Europe PubMed Central

12 October 2017

L Y Lian

4

1 reference

Europe PubMed Central

12 October 2017

M J Sutcliffe

5

1 reference

Europe PubMed Central

12 October 2017

M P Pritchard

6

1 reference

Europe PubMed Central

12 October 2017

T Friedberg

7

1 reference

Europe PubMed Central

12 October 2017

G C Roberts

8

1 reference

Europe PubMed Central

12 October 2017

C R Wolf

9

1 reference

Europe PubMed Central

12 October 2017

language of work or name

0 references

publication date

1 May 1998

1 reference

Europe PubMed Central

12 October 2017

Biochemical Journal

1 reference

Europe PubMed Central

12 October 2017

331 ( Pt 3)

1 reference

Europe PubMed Central

12 October 2017

783-792

1 reference

Europe PubMed Central

12 October 2017

Protein measurement with the Folin phenol reagent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

An automated approach for defining core atoms and domains in an ensemble of NMR-derived protein structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Crystal structure and refinement of cytochrome P450terp at 2.3 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Clinical implications of genetic polymorphism in drug metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Structure of cytochrome P450eryF involved in erythromycin biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Effect of replacement of ferriprotoporphyrin IX in the haem domain of cytochrome P-450 BM-3 on substrate binding and catalytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Pretranslational regulation of sex-dependent testosterone hydroxylases by growth hormone in mouse liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Crystal structure of substrate-free Pseudomonas putida cytochrome P-450

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

High-resolution crystal structure of cytochrome P450cam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

The molecular biology of cytochrome P450s.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16) alpha) in mouse liver: cDNA sequences, neonatal imprinting, and reversible regulation by androgen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Functional characterization of two cytochrome P-450s within the mouse, male-specific steroid 16 alpha-hydroxylase gene family: expression in mammalian cells and chimeric proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Microbial cytochromes P-450 and xenobiotic metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

The surface-exposed tyrosine residue Tyr83 of pea plastocyanin is involved in both binding and electron transfer reactions with cytochrome f

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

The Protein Data Bank: a computer-based archival file for macromolecular structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

DNA sequencing with chain-terminating inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

6 June 2018

A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

18 August 2018

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

18 August 2018

Nomenclature for human CYP2D6 alleles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

18 August 2018

Structure and function of cytochromes P450: a comparative analysis of three crystal structures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219418

18 August 2018

Mouse liver testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha). Purification, regioselectivity, stereospecificity, and immunochemical characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic polymorphism in drug oxidation: in vitro studies of human debrisoquine 4-hydroxylase and bufuralol 1'-hydroxylase activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing Structure-Function Relations in Heme-Containing Oxygenases and Peroxidases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificities of cytochrome P-450, C-P-450(16)alpha and P-450(15)alpha, and contribution to steroid hydroxylase activities in mouse liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cytochrome P450 2D6 in Escherichia coli, purification, and spectral and catalytic characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a Substrate of Cytochrome P450 2D6: Allosteric Effects of NADPH−Cytochrome P450 Reductase†

1 reference

https://pubmed.ncbi.nlm.nih.gov/9560305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ3310783

1 reference

Europe PubMed Central

12 October 2017

1 reference

Europe PubMed Central

12 October 2017

1 reference

Europe PubMed Central

12 October 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q41806994&oldid=1927932306"