Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease (Q41814137)

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scientific article published on 8 February 2012

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English	Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease	scientific article published on 8 February 2012

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scholarly article

1 reference

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22 January 2020

Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease (English)

1 reference

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22 January 2020

blood–brain barrier

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Henk-Jan Drenth

2

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22 January 2020

Elizabeth C de Lange

5

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22 January 2020

Meindert Danhof

4

object named as

Meindert Danhof

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22 January 2020

author name string

Paulien Gm Ravenstijn

1

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22 January 2020

Michael J O'Neill

3

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22 January 2020

publication date

8 February 2012

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22 January 2020

Fluids and Barriers of the CNS

1 reference

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22 January 2020

9

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22 January 2020

4

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22 January 2020

https://scigraph.springernature.com/pub.10.1186/2045-8118-9-4

0 references

Structure and function of the blood-brain barrier

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6 June 2018

The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies

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Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2.

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6 June 2018

Current status of symptomatic medical therapy in Parkinson's disease

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6 June 2018

Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA.

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Motor complications in Parkinson disease: clinical manifestations and management

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Endothelial proliferation and increased blood-brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia.

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6 June 2018

Protective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline against dopaminergic neurodegeneration in the extrapyramidal structures produced by intracerebral injection of rotenone

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The origin of motor fluctuations in Parkinson's disease: importance of dopaminergic innervation and basal ganglia circuits.

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Parkinson's disease: mechanisms and models

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6 June 2018

Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells

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6 June 2018

Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease

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6 June 2018

Dopamine synthesis, uptake, metabolism, and receptors: relevance to gene therapy of Parkinson's disease

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6 June 2018

On the origin of dopamine and its metabolite in predominantly noradrenergic innervated brain areas.

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6 June 2018

Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight.

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6 June 2018

Dopamine release in vivo from nigrostriatal, mesolimbic, and mesocortical neurons: utility of 3-methoxytyramine measurements

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6 June 2018

Homovanillic acid measurement in clinical research: a review of methodology

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6 June 2018

Assessment of dopamine and its metabolites in the intracellular and extracellular compartments of the rat striatum after peripheral administration of L-[11C]dopa.

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6 June 2018

Characteristics of catechol O-methyl-transferase (COMT) and properties of selective COMT inhibitors

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6 June 2018

Biotransformation of L-dopa in striatum and substantia nigra of rats with a unilateral, nigrostriatal lesion: a microdialysis study

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6 June 2018

Levodopa pharmacokinetics. Alterations after benserazide, a decarboxylase inhibitor

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6 June 2018

Reduction of L-type amino acid transporter 1 mRNA expression in brain capillaries in a mouse model of Parkinson's disease

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18 August 2018

Sequence and significance of dopamine metabolism in the rat brain.

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18 August 2018

Blood-brain barrier P-glycoprotein function is not impaired in early Parkinson's disease.

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18 August 2018

The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments.

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18 August 2018

Dopamine turnover is upregulated in the caudate/putamen of asymptomatic MPTP-treated rhesus monkeys.

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18 August 2018

6-Hydroxydopamine-induced alterations in blood-brain barrier permeability

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Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine

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Increased caudate dopamine turnover may contribute to the recovery of motor function in marmosets treated with the dopaminergic neurotoxin MPTP

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12 December 2020

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Striatal L-dopa metabolism studied in vivo in rats with nigrostriatal lesions

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12 December 2020

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Effect of plasma levels of large neutral amino acids and degree of parkinsonism on the blood-to-brain transport of levodopa in naive and MPTP parkinsonian monkeys

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12 December 2020

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Determination of conjugated monoamine metabolites in brain tissue

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12 December 2020

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Microdialysis for pharmacokinetic analysis of drug transport to the brain

1 reference

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12 December 2020

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6-fluoroDOPA metabolism in rat striatum: time course of extracellular metabolites

1 reference

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12 December 2020

based on heuristic

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Pharmacokinetic and pharmacodynamic studies of L-dopa in rats. II. Effect of L-dopa on dopamine and dopamine metabolite concentration in rat striatum

1 reference

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12 December 2020

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The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport

1 reference

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12 December 2020

based on heuristic

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Pharmacokinetic and pharmacodynamic studies of L-dopa in rats. I. Pharmacokinetic analysis of L-dopa in rat plasma and striatum

1 reference

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12 December 2020

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10.1186/2045-8118-9-4

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22 January 2020

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24 November 2022

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22 January 2020

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22 January 2020

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