AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. (Q41818439)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590629%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist (English)

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6 February 2020

6

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11

Geoffrey Burnstock

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6 February 2020

author name string

Joel R Gever

1

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6 February 2020

Rothschild Soto

2

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6 February 2020

Robert A Henningsen

3

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Renee S Martin

4

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6 February 2020

David H Hackos

5

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6 February 2020

Werner Rubas

7

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6 February 2020

Ian B Oglesby

8

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6 February 2020

Michael P Dillon

9

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6 February 2020

Marcos E Milla

10

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6 February 2020

Anthony P D W Ford

12

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language of work or name

English

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publication date

1 July 2010

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British Journal of Pharmacology

6 February 2020

published in

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volume

160

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issue

6

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6 February 2020

page(s)

1387-1398

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Homomeric and heteromeric P2X3 receptors in peripheral sensory neurons.

6 February 2020

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Pharmacologic management of neuropathic pain: evidence-based recommendations

6 June 2018

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Physiology and pathophysiology of purinergic neurotransmission

6 June 2018

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Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study

6 June 2018

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Pharmacology of P2X channels

6 June 2018

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Vesicular release of ATP at central synapses

6 June 2018

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Purinoceptors as therapeutic targets for lower urinary tract dysfunction

6 June 2018

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ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells

6 June 2018

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Cellular distribution and functions of P2 receptor subtypes in different systems

6 June 2018

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siRNA relieves chronic neuropathic pain

6 June 2018

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Some quantitative uses of drug antagonists

6 June 2018

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2', 3'-O-(2,4,6,trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X3 receptor

6 June 2018

1 reference

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P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine

6 June 2018

1 reference

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Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit

6 June 2018

1 reference

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A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.

6 June 2018

1 reference

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Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats

6 June 2018

1 reference

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Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue

6 June 2018

1 reference

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Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

6 June 2018

1 reference

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Regulated expression of the rat recombinant P2X(3) receptor in stably transfected CHO-K1 tTA cells

6 June 2018

1 reference

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Pharmacology of cloned P2X receptors

6 June 2018

1 reference

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Pharmacological properties of P2X3-receptors present in neurones of the rat dorsal root ganglia.

6 June 2018

1 reference

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Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors.

6 June 2018

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Domains of P2X receptors involved in desensitization

6 June 2018

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Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

6 June 2018

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A P2X purinoceptor expressed by a subset of sensory neurons

6 June 2018

1 reference

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

6 June 2018

1 reference

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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.

6 June 2018

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Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain

6 June 2018

1 reference

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Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain

18 August 2018

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Guide to Receptors and Channels (GRAC), 3rd edition

18 August 2018

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Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats.

18 August 2018

1 reference

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Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius.

18 August 2018

1 reference

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Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2938810

Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain.

18 August 2018

1 reference

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TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics

18 August 2018

1 reference

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Interstitial cells of Cajal in diabetic gastroenteropathy

18 August 2018

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Crossref

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00796.X

The Uptake of Atropine and Related Drugs by Intestinal Smooth Muscle of the Guinea-Pig in Relation to Acetylcholine Receptors

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00796.X

P2X3 is expressed by DRG neurons that terminate in inner lamina II

21 January 2018

1 reference

12 December 2020

The journey to establish purinergic signalling in the gut

1 reference

12 December 2020

Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP)

1 reference

12 December 2020

A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats

1 reference

12 December 2020

10.1111/J.1476-5381.2010.00796.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590629%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590629%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

20590629

1 reference