p53 activates transcription by directing structural shifts in Mediator (Q41824511)

12 October 2017

p53 activates transcription by directing structural shifts in Mediator (English)

1 reference

12 October 2017

Krista D Meyer

1

1 reference

12 October 2017

Shih-Chieh Lin

2

1 reference

12 October 2017

Carrie Bernecky

3

1 reference

12 October 2017

Yuefeng Gao

4

1 reference

12 October 2017

Dylan J Taatjes

5

1 reference

12 October 2017

9 May 2010

1 reference

Nature Structural & Molecular Biology

12 October 2017

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12 October 2017

17

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12 October 2017

6

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12 October 2017

753-760

1 reference

https://scigraph.springernature.com/pub.10.1038/nsmb.1816

12 October 2017

0 references

cites work

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The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

6 June 2018

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Mediator-dependent recruitment of TFIIH modules in preinitiation complex

6 June 2018

1 reference

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Regulation of p53 target gene expression by peptidylarginine deiminase 4

6 June 2018

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Mechanisms of regulatory diversity within the p53 transcriptional network

6 June 2018

1 reference

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RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes.

6 June 2018

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An acetylation switch in p53 mediates holo-TFIID recruitment

6 June 2018

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Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications

6 June 2018

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

6 June 2018

1 reference

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Restoration of p53 function leads to tumour regression in vivo

6 June 2018

1 reference

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The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Breaking barriers to transcription elongation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Dynamic regulation of pol II transcription by the mammalian Mediator complex

6 June 2018

1 reference

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Mediator and the mechanism of transcriptional activation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Mediator requirement for both recruitment and postrecruitment steps in transcription initiation

6 June 2018

1 reference

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Negative staining and image classification — powerful tools in modern electron microscopy

6 June 2018

1 reference

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The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Modulation of mammalian life span by the short isoform of p53.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

A novel docking site on Mediator is critical for activation by VP16 in mammalian cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Cryo-negative staining reduces electron-beam sensitivity of vitrified biological particles.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Structure, function, and activator-induced conformations of the CRSP coactivator

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

p53 mutant mice that display early ageing-associated phenotypes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Dissecting the regulatory circuitry of a eukaryotic genome

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Activator-mediated recruitment of the RNA polymerase II machinery is the predominant mechanism for transcriptional activation in yeast

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Activation of transcription in vitro by recruitment of the yeast RNA polymerase II holoenzyme

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-kappaB and Sp1.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Assembly of the isomerized TFIIA--TFIID--TATA ternary complex is necessary and sufficient for gene activation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Human TAFII31 protein is a transcriptional coactivator of the p53 protein

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

p53 must be competent for transcriptional regulation to suppress tumor formation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

p53 linear diffusion along DNA requires its C terminus

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Distinct conformational states of nuclear receptor-bound CRSP-Med complexes

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

The immobilized template assay for measuring cooperativity in eukaryotic transcription complex assembly.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemogenesis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Activator-induced conformational change in general transcription factor TFIIB.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2932482

Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction

18 August 2018

1 reference

Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53

31 March 2020

1 reference

Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS

31 March 2020

1 reference

Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.1816

1 reference

Dimensions Publication ID

12 October 2017

0 references

1 reference

12 October 2017

1 reference