A novel CUG(exp)·MBNL1 inhibitor with therapeutic potential for myotonic dystrophy type 1. (Q41825220)

12 October 2017

A novel CUG(exp)·MBNL1 inhibitor with therapeutic potential for myotonic dystrophy type 1. (English)

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12 October 2017

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Amin Haghighat Jahromi

1

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12 October 2017

Lien Nguyen

2

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12 October 2017

Yuan Fu

3

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12 October 2017

Kali A Miller

4

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12 October 2017

Anne M Baranger

5

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12 October 2017

Steven C Zimmerman

6

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12 October 2017

20 March 2013

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12 October 2017

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12 October 2017

8

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12 October 2017

5

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12 October 2017

1037-1043

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describes a project that uses

12 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3683132/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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From dynamic combinatorial 'hit' to lead: in vitro and in vivo activity of compounds targeting the pathogenic RNAs that cause myotonic dystrophy

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Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive

6 June 2018

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New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats

6 June 2018

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Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.

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6 June 2018

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6 June 2018

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6 June 2018

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Ribonuclear foci at the neuromuscular junction in myotonic dystrophy type 1.

6 June 2018

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Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy

6 June 2018

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Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy

6 June 2018

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6 June 2018

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6 June 2018

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6 June 2018

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6 June 2018

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Identification of intron and exon sequences involved in alternative splicing of insulin receptor pre-mRNA.

6 June 2018

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Spatial consequences of defective processing of specific yeast mRNAs revealed by fluorescent in situ hybridization

6 June 2018

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Synthesis of linear polyamines with different amine spacings and their ability to form dsDNA/siRNA complexes suitable for transfection.

6 June 2018

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Study by optical spectroscopy and molecular dynamics of the interaction of acridine-spermine conjugate with DNA.

18 August 2018

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Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

18 August 2018

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12 December 2020

A Structural Basis for RNAminus signLigand Interactions

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12 December 2020

A reversal of misfortune for myotonic dystrophy?

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12 December 2020

Targeting RNA with small molecules

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12 December 2020

Targeting RNA with Small Molecules

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1021/CB400046U

1 reference

12 October 2017

1 reference

12 October 2017

1 reference