Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation. (Q41827191)

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scientific article published on 31 August 2010

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English	Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation.	scientific article published on 31 August 2010

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scholarly article

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13 February 2020

Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation (English)

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13 February 2020

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reactive oxygen species

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Christoph Zechner

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13 February 2020

author name string

Heiko Bugger

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13 February 2020

Cinthia Guzman

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13 February 2020

Monica Palmeri

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13 February 2020

Kerry S Russell

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13 February 2020

Raymond R Russell

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13 February 2020

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31 August 2010

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13 February 2020

Cancer Chemotherapy and Pharmacology

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13 February 2020

67

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13 February 2020

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13 February 2020

1381-1388

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13 February 2020

https://scigraph.springernature.com/pub.10.1007/s00280-010-1441-7

0 references

Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats

1 reference

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6 June 2018

Attenuation of doxorubicin-induced cardiac injury by mitochondrial glutaredoxin 2.

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6 June 2018

New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics.

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6 June 2018

Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity

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6 June 2018

P/O ratios of mitochondrial oxidative phosphorylation

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6 June 2018

Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading

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6 June 2018

Role of mitochondria in oxidative stress and aging

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6 June 2018

The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3

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6 June 2018

Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice

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6 June 2018

Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging, and heart failure

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6 June 2018

In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism

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6 June 2018

Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

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6 June 2018

Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR

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6 June 2018

Energy metabolism in uncoupling protein 3 gene knockout mice

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6 June 2018

Cooperation of a "reactive oxygen cycle" with the Q cycle and the proton cycle in the respiratory chain--superoxide generating and cycling mechanisms in mitochondria

1 reference

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6 June 2018

Insulin does not change the intracellular distribution of hexokinase in rat heart.

1 reference

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6 June 2018

Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.

1 reference

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6 June 2018

Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems

1 reference

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6 June 2018

Generating, partitioning, targeting and functioning of superoxide in mitochondria

1 reference

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6 June 2018

Effects of adriamycin on respiratory chain activities in mitochondria from rat liver, rat heart and bovine heart. Evidence for a preferential inhibition of complex III and IV.

1 reference

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6 June 2018

Oxidative and non-oxidative mechanisms in the inactivation of cardiac mitochondrial electron transport chain components by doxorubicin.

1 reference

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6 June 2018

Structure of the adriamycin-cardiolipin complex. Role in mitochondrial toxicity

1 reference

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6 June 2018

Oxygen free radicals and congestive heart failure

1 reference

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6 June 2018

Coenzyme A sequestration in rat hearts oxidizing ketone bodies

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6 June 2018

Adaptation of mitochondrial ATP production in human skeletal muscle to endurance training and detraining

1 reference

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6 June 2018

Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin.

1 reference

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18 August 2018

Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the development of cardiac apoptosis.

1 reference

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18 August 2018

Mitochondrial uncoupling protein 1 expressed in the heart of transgenic mice protects against ischemic-reperfusion damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3051028

18 August 2018

Mitochondrials complex I activity is reduced in latent adriamycin-induced cardiomyopathy of rat.

1 reference

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18 August 2018

Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3051028

18 August 2018

Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles.

1 reference

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18 August 2018

Stable transfection of UCP1 confers resistance to hypoxia/reoxygenation in a heart-derived cell line.

1 reference

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18 August 2018

Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio.

1 reference

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18 August 2018

Early changes in myocardial antioxidant enzymes in rats treated with adriamycin

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3051028

18 August 2018

Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle

1 reference

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18 August 2018

Mitochondrial ATPase and high-energy phosphates in failing hearts

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18 August 2018

Overexpression of UCP3 in cultured human muscle lowers mitochondrial membrane potential, raises ATP/ADP ratio, and favors fatty acid vs. glucose oxidation.

1 reference

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18 August 2018

Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes

1 reference

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18 August 2018

Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3051028

18 August 2018

A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians

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21 January 2018

Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population

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21 January 2018

Bcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809120

12 December 2020

based on heuristic

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Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809120

12 December 2020

based on heuristic

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Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809120

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mitochondrial oxidative phosphorylation by adriamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809120

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of adriamycin on electron transport in rat heart, liver, and tumor mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809120

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP production rate in mitochondria isolated from microsamples of human muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809120

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mitochondrial carnitine palmitoyltransferases by adriamycin and adriamycin analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809120

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of oxidative stress in chronic heart failure in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809120

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further evidence that lucigenin-derived chemiluminescence monitors mitochondrial superoxide generation in rat alveolar macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809120

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809120

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/20809120

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00280-010-1441-7

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13 February 2020

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13 February 2020

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13 February 2020

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