Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry. (Q41864920)

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28 February 2020

title

Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry (English)

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28 February 2020

5

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28 February 2020

author name string

Wolfgang Schaefer

1

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28 February 2020

Hans R Völger

2

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28 February 2020

Stefan Lorenz

3

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28 February 2020

Sabine Imhof-Jung

4

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28 February 2020

Christian Klein

6

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28 February 2020

Michael Mølhøj

7

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publication date

23 October 2015

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28 February 2020

published in

Monoclonal Antibodies

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28 February 2020

volume

8

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28 February 2020

issue

1

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28 February 2020

page(s)

49-55

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Alternative molecular formats and therapeutic applications for bispecific antibodies

28 February 2020

cites work

1 reference

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A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism.

5 June 2018

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Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface

5 June 2018

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Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy

5 June 2018

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Improving biophysical properties of a bispecific antibody scaffold to aid developability

5 June 2018

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A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties

5 June 2018

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A novel angiopoietin-2 selective fully human antibody with potent anti-tumoral and anti-angiogenic efficacy and superior side effect profile compared to Pan-Angiopoietin-1/-2 inhibitors

5 June 2018

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Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies.

5 June 2018

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Symmetry breaking: bispecific antibodies, the beginnings, and 50 years on

5 June 2018

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Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair

5 June 2018

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Dual targeting strategies with bispecific antibodies

5 June 2018

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A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens

5 June 2018

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Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

5 June 2018

1 reference

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Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling

5 June 2018

1 reference

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Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.

5 June 2018

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Bispecific human IgG by design

5 June 2018

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Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders

5 June 2018

1 reference

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Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies

5 June 2018

1 reference

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Restricted reassociation of heavy and light chains from hapten-specific monoclonal antibodies

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966523

Structural basis for the preferential association of autologous immunoglobulin subunits: role of the J region of the light chain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4966523

The specificity of chain interactions among immunoglobulins. Combinations of gamma chains with kappa chains of the same subgroup as in the parent immunoglobulin G.

5 June 2018

1 reference

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The role of the VL- and VH-segments in the preferential reassociation of immunoglobulin subunits

5 June 2018

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Advantages of bispecific hybridomas in one-step immunocytochemistry and immunoassays

5 June 2018

1 reference

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A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model

5 June 2018

1 reference

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VH/VL interface engineering to promote selective expression and inhibit conformational isomerization of thrombopoietin receptor agonist single-chain diabody.

18 August 2018

1 reference

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Hybrid hybridomas and their use in immunohistochemistry

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1080%2F19420862.2015.1111498

'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization

21 January 2018

1 reference

12 December 2020

Bispecific monoclonal antibodies from hybrid hybridomas

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12 December 2020

Immunoglobulins Secreted by a Hybrid-Hybridoma: Analysis of Chain Assemblies

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12 December 2020

Germline VH/VL pairing in antibodies

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12 December 2020

Relative noncovalent association constant between immunoglobulin H and L chains is unrelated to their expression or antigen-binding activity

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12 December 2020

Specific interaction between VH and VL regions of human monoclonal immunoglobulins

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12 December 2020

Bispecific antibody-producing hybrid hybridoma and its use in one-step immunoassays for human lymphotoxin

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12 December 2020

Absence of preferential homologous H/L chain association in hybrid hybridomas

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12 December 2020

Pairing of variable heavy and variable kappa chains in individual naive and memory B cells

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12 December 2020

10.1080/19420862.2015.1111498

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26496506%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

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28 February 2020

PubMed publication ID

26496506

1 reference