Allosteric modulation of the activity of thrombin (Q41878350)

13 October 2017

Allosteric modulation of the activity of thrombin (English)

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13 October 2017

Duffy EJ

1

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13 October 2017

Angliker H

series ordinal

2

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13 October 2017

Le Bonniec BF

series ordinal

3

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13 October 2017

Stone SR

series ordinal

4

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13 October 2017

language of work or name

English

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publication date

1 January 1997

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13 October 2017

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13 October 2017

321 ( Pt 2)

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13 October 2017

361-365

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Synthesis of oligopeptide chloromethanes to investigate extended binding regions of proteinases: application to the interaction of fibrinogen with thrombin

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

The linkage between binding of the C-terminal domain of hirudin and amidase activity in human alpha-thrombin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

The clot thickens: clues provided by thrombin structure.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

Kinetics of the inhibition of thrombin by hirudin.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

Recombinant human protein C derivatives: altered response to calcium resulting in enhanced activation by thrombin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

Structure of the hirugen and hirulog 1 complexes of alpha-thrombin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

Allosteric changes in thrombin's activity produced by peptides corresponding to segments of natural inhibitors and substrates

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

Domains specifying thrombin–receptor interaction

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1218077

63 Inactivation of trypsin-like enzymes with peptides of arginine chloromethyl ketone

18 August 2018

1 reference

12 December 2020

Characterization of the P2' and P3' specificities of thrombin using fluorescence-quenched substrates and mapping of the subsites by mutagenesis

1 reference

12 December 2020

Use of fragments of hirudin to investigate thrombin-hirudin interaction

1 reference

12 December 2020

The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity

1 reference

12 December 2020

The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation

1 reference

12 December 2020

The role of calcium ions in factor X activation by thrombin E192Q

1 reference

12 December 2020

Enhancing protein C interaction with thrombin results in a clot-activated anticoagulant

1 reference

12 December 2020

Solution structure of a platelet receptor peptide bound to bovine alpha-thrombin

1 reference

12 December 2020

Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate

1 reference

12 December 2020

Identification of thrombin residues that modulate its interactions with antithrombin III and alpha 1-antitrypsin

1 reference

12 December 2020

Solution composition dependent variation in extinction coefficients for p-nitroaniline

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ3210361

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13 October 2017

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13 October 2017

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