Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity. (Q41882222)

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scientific article published on May 2009

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English	Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity.	scientific article published on May 2009

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scholarly article

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26 January 2020

Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity (English)

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26 January 2020

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7

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26 January 2020

Michael R. Betts

8

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Michael R Betts

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26 January 2020

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George Makedonas

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26 January 2020

Pinaki P Banerjee

2

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26 January 2020

Rahul Pandey

3

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26 January 2020

Adam R Hersperger

4

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26 January 2020

Keri B Sanborn

5

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26 January 2020

Gareth A D Hardy

6

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26 January 2020

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1 May 2009

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26 January 2020

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10

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Journal of Immunology

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26 January 2020

182

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26 January 2020

9

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26 January 2020

5560-5569

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26 January 2020

Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse.

1 reference

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Apoptosis induced by the lymphocyte effector molecule perforin

1 reference

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Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4

1 reference

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Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation, and proliferation in CD8 T cells of patients with human immunodeficiency virus-1 (HIV)

1 reference

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Perforin-mediated target-cell death and immune homeostasis

1 reference

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Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

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Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

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Unlocking the secrets of cytotoxic granule proteins

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Liposomes as targets for granule cytolysin from cytotoxic large granular lymphocyte tumors

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Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules

1 reference

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Interaction of chondroitin sulfate with perforin and granzymes of cytolytic T-cells is dependent on pH.

1 reference

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5 June 2018

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

1 reference

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5 June 2018

A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

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Cytotoxic T lymphocyte sequential killing of immobilized allogeneic tumor target cells measured by time-lapse microcinematography

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The mechanism of T cell mediated cytotoxicity I. The release of different cell components

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Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry.

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Induction of cytotoxic granules in human memory CD8+ T cell subsets requires cell cycle progression.

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T cells use two directionally distinct pathways for cytokine secretion.

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Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

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1 reference

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12 December 2020

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Evidence that glycoprotein 96 (B2), a stress protein, functions as a Th2-specific costimulatory molecule

1 reference

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HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

1 reference

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12 December 2020

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Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

1 reference

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Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1 reference

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T cell receptor-induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A

1 reference

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1 reference

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Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19380804

12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.0803945

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Europe PubMed Central

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26 January 2020

1 reference

Europe PubMed Central

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26 January 2020

1 reference

Europe PubMed Central

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26 January 2020

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