Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. (Q41885676)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19619138%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model (English)

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2 February 2020

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9

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2 February 2020

Jennifer C. Tudor

1

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2 February 2020

Jose Morales-Corraliza

4

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2 February 2020

Stephen D Ginsberg

7

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2 February 2020

author name string

Jason D Berger

2

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2 February 2020

Matthew J Mazzella

3

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2 February 2020

Anne M Cataldo

5

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2 February 2020

Ralph A Nixon

6

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2 February 2020

Efrat Levy

8

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2 February 2020

language of work or name

English

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publication date

10 July 2009

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Journal of Neurochemistry

2 February 2020

published in

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2 February 2020

volume

110

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2 February 2020

issue

6

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page(s)

1818-1827

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The coming of age of axonal neurotrophin signaling endosomes

2 February 2020

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5 June 2018

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Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome

5 June 2018

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Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome

5 June 2018

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Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.

5 June 2018

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App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

5 June 2018

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Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory

5 June 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

5 June 2018

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Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments

5 June 2018

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Nerve growth factor signaling, neuroprotection, and neural repair

5 June 2018

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Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

5 June 2018

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Amyloid precursor protein and membrane phospholipids in primary cortical neurons increase with development, or after exposure to nerve growth factor or Abeta(1-40)

5 June 2018

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Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

5 June 2018

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

5 June 2018

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Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases

5 June 2018

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Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

5 June 2018

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Amyloid precursor protein potentiates the neurotrophic activity of NGF.

5 June 2018

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Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

5 June 2018

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Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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Gene expression profiling in the adult Down syndrome brain.

5 June 2018

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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

18 August 2018

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Evidence against the overexpression of APP in Down syndrome.

18 August 2018

1 reference

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ELISA method for measurement of amyloid-beta levels.

18 August 2018

1 reference

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Tissue processing prior to protein analysis and amyloid-beta quantitation.

18 August 2018

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Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice

18 August 2018

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Global disruption of the cerebellar transcriptome in a Down syndrome mouse model

18 August 2018

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Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome

18 August 2018

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Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

18 August 2018

1 reference

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Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice.

18 August 2018

1 reference

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Spatial memory deficits in segmental trisomic Ts65Dn mice.

18 August 2018

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Transcriptome analysis of human autosomal trisomy

18 August 2018

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12 December 2020

NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals

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12 December 2020

An analysis of the morphology of senile plaques in Down's syndrome patients of different ages using immunocytochemical and lectin histochemical techniques

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12 December 2020

Amyloid precursor protein metabolism in primary cell cultures of neurons, astrocytes, and microglia

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12 December 2020

10.1111/J.1471-4159.2009.06277.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19619138%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19619138%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

19619138

1 reference