Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion. (Q41910421)

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1 January 2020

title

Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion (English)

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1 January 2020

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3

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1 January 2020

Rossella Menghini

4

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Fatima Bosch

9

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1 January 2020

Giorgio Sesti

10

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Massimo Federici

11

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1 January 2020

author name string

Marta L Hribal

1

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1 January 2020

F Tornei

2

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1 January 2020

D Barcaroli

5

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D Lauro

6

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R Amoruso

7

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R Lauro

8

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1 January 2020

publication date

19 January 2008

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Journal of Cellular and Molecular Medicine

1 January 2020

published in

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volume

12

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1 January 2020

page(s)

2096-2106

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1 January 2020

issue

5B

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Genetic prediction of future type 2 diabetes

1 January 2020

cites work

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5 June 2018

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5 June 2018

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5 June 2018

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Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

5 June 2018

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The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets

5 June 2018

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The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells

5 June 2018

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Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

5 June 2018

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The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells

5 June 2018

1 reference

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A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies

5 June 2018

1 reference

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Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle.

5 June 2018

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Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance

18 August 2018

1 reference

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The G972R variant of the insulin receptor substrate-1 (IRS-1) gene is associated with insulin resistance in "uncomplicated" obese subjects evaluated by hyperinsulinemic-euglycemic clamp

18 August 2018

1 reference

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Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation

18 August 2018

1 reference

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The insulin receptor substrate-1 Gly972Arg polymorphism is not associated with Type 2 diabetes mellitus in two population-based studies

18 August 2018

1 reference

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The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

18 August 2018

1 reference

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Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study

18 August 2018

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G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells.

18 August 2018

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Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies

18 August 2018

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Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

18 August 2018

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Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.

18 August 2018

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Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus.

18 August 2018

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Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.

18 August 2018

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Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18208559

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1582-4934.2008.00246.X

1 reference

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1 January 2020

1 reference

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1 January 2020

1 reference