Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs (Q41916522)

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scientific article published on 26 October 2015

Language	Label	Description	Also known as
English	Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs	scientific article published on 26 October 2015

Statements

scholarly article

1 reference

Europe PubMed Central

14 October 2017

Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs (English)

1 reference

Europe PubMed Central

14 October 2017

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Plasmodium falciparum

1 reference

based on heuristic

inferred from title

Robert L Summers

object named as

Robert L Summers

4

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object named as

Rowena E Martin

7

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object named as

Adele M Lehane

5

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author name string

Donelly A van Schalkwyk

1

1 reference

Europe PubMed Central

14 October 2017

Megan N Nash

2

1 reference

Europe PubMed Central

14 October 2017

Sarah H Shafik

3

1 reference

Europe PubMed Central

14 October 2017

Peter J Smith

6

1 reference

Europe PubMed Central

14 October 2017

language of work or name

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publication date

26 October 2015

1 reference

Europe PubMed Central

14 October 2017

Journal of Infectious Diseases

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Europe PubMed Central

14 October 2017

213

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Europe PubMed Central

14 October 2017

5

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Europe PubMed Central

14 October 2017

800-810

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Europe PubMed Central

14 October 2017

Spread of artemisinin resistance in Plasmodium falciparum malaria

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Chloroquine transport via the malaria parasite's chloroquine resistance transporter

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https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Mode of antimalarial effect of methylene blue and some of its analogues on Plasmodium falciparum in culture and their inhibition of P. vinckei petteri and P. yoelii nigeriensis in vivo

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Interactions of the antimalarial drug methylene blue with methemoglobin and heme targets in Plasmodium falciparum: a physico-biochemical study

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Alkalinization of the food vacuole of malaria parasites by quinoline drugs and alkylamines is not correlated with their antimalarial activity

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Acridine Orange for malaria diagnosis: its diagnostic performance, its promotion and implementation in Tanzania, and the implications for malaria control

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive or resistant to chloroquine

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Antimalarial drugs inhibiting hemozoin (beta-hematin) formation: a mechanistic update

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Discovery of dual function acridones as a new antimalarial chemotype

1 reference

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21 January 2018

Acridine and acridinones: old and new structures with antimalarial activity

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children: a randomized controlled trial in Burkina Faso

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Haemolysis risk in methylene blue treatment of G6PD-sufficient and G6PD-deficient West-African children with uncomplicated falciparum malaria: a synopsis of four RCTs

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Activity of pyronaridine and mepacrine against twelve strains of Plasmodium falciparum in vitro

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

In vitro activity of Proveblue (methylene blue) on Plasmodium falciparum strains resistant to standard antimalarial drugs

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazines

1 reference

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21 January 2018

Baseline in vitro activities of the antimalarials pyronaridine and methylene blue against Plasmodium falciparum isolates from Kenya

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Potent Ex Vivo Activity of Naphthoquine and Methylene Blue against Drug-Resistant Clinical Isolates of Plasmodium falciparum and Plasmodium vivax

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Reversal of chloroquine resistance in Plasmodium falciparum by verapamil

1 reference

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21 January 2018

Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Saquinavir inhibits the malaria parasite's chloroquine resistance transporter.

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIV509

21 January 2018

Soft X-ray microscopy analysis of cell volume and hemoglobin content in erythrocytes infected with asexual and sexual stages of Plasmodium falciparum

1 reference

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21 January 2018

Protein export marks the early phase of gametocytogenesis of the human malaria parasite Plasmodium falciparum

1 reference

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21 January 2018

Functional characteristics of the malaria parasite's "chloroquine resistance transporter": implications for chemotherapy

1 reference

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21 January 2018

Identifiers

10.1093/INFDIS/JIV509

1 reference

Europe PubMed Central

14 October 2017

1 reference

Europe PubMed Central

14 October 2017

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