PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation (Q41918159)

14 October 2017

title

PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation (English)

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14 October 2017

1

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1 June 2020

Hiroyuki Morino

4

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1 June 2020

Hideshi Kawakami

7

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1 June 2020

Takashi Yamamoto

8

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1 June 2020

Shinya Matsuura

11

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1 June 2020

author name string

Silvia Natsuko Akutsu

2

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1 June 2020

Akihiro Fukumitsu

3

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1 June 2020

Yoshinori Masatsuna

5

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1 June 2020

Kosuke Hosoba

6

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1 June 2020

Kenji Shimizu

9

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1 June 2020

Hirofumi Ohashi

10

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1 June 2020

publication date

26 August 2017

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14 October 2017

published in

Human Molecular Genetics

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1 June 2020

volume

26

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1 June 2020

issue

22

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1 June 2020

page(s)

4429-4440

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What next-generation sequencing (NGS) technology has enabled us to learn about primary autosomal recessive microcephaly (MCPH).

1 June 2020

cites work

1 reference

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Genetic causes of microcephaly and lessons for neuronal development

21 January 2018

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Centrioles, centrosomes, and cilia in health and disease

21 January 2018

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Regulation of mitotic spindle orientation: an integrated view.

21 January 2018

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Mitotic spindle (DIS)orientation and DISease: cause or consequence?

21 January 2018

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Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

WDR62 is associated with the spindle pole and is mutated in human microcephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex

21 January 2018

1 reference

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Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

The Microcephaly-Associated Protein Wdr62/CG7337 Is Required to Maintain Centrosome Asymmetry in Drosophila Neuroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes

21 January 2018

1 reference

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Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

WD40-repeat protein 62 is a JNK-phosphorylated spindle pole protein required for spindle maintenance and timely mitotic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX330

21 January 2018

Identifiers

DOI

10.1093/HMG/DDX330

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28973348%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference