Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth. (Q41927912)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23114783%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth (English)

1 reference

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16 February 2020

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2

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16 February 2020

author name string

Alexander P Gorka

1

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16 February 2020

Katy S Sherlach

3

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16 February 2020

Lauren M Jacobs

4

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16 February 2020

Katherine B Nickley

5

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16 February 2020

Jonathan P Brower

6

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16 February 2020

Angel C de Dios

7

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16 February 2020

Paul D Roepe

8

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16 February 2020

language of work or name

English

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publication date

31 October 2012

1 reference

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Antimicrobial Agents and Chemotherapy

16 February 2020

published in

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16 February 2020

volume

57

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16 February 2020

issue

1

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16 February 2020

page(s)

356-364

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Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum

16 February 2020

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1 reference

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Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum

5 June 2018

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A major genome region underlying artemisinin resistance in malaria

5 June 2018

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Plasmodium falciparum resistance to cytocidal versus cytostatic effects of chloroquine

5 June 2018

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5 June 2018

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The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex.

5 June 2018

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Reduced digestive vacuolar accumulation of chloroquine is not linked to resistance to chloroquine toxicity

5 June 2018

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Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain.

5 June 2018

1 reference

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Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria

5 June 2018

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Antimalarial drugs and heme in detergent micelles: An NMR study.

5 June 2018

1 reference

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Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas

5 June 2018

1 reference

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Photoaffinity labeling of the Plasmodium falciparum chloroquine resistance transporter with a novel perfluorophenylazido chloroquine

5 June 2018

1 reference

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Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium

5 June 2018

1 reference

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4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria

5 June 2018

1 reference

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Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines

5 June 2018

1 reference

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Antimalarial dosing regimens and drug resistance

5 June 2018

1 reference

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Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine

5 June 2018

1 reference

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Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds

5 June 2018

1 reference

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The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization.

5 June 2018

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pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum

5 June 2018

1 reference

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Quinoline antimalarials decrease the rate of beta-hematin formation

5 June 2018

1 reference

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A colorimetric high-throughput beta-hematin inhibition screening assay for use in the search for antimalarial compounds

5 June 2018

1 reference

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Structure of the amodiaquine-FPIX mu oxo dimer solution complex at atomic resolution

5 June 2018

1 reference

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Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum

5 June 2018

1 reference

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Dissecting the loci of low-level quinine resistance in malaria parasites

5 June 2018

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Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy.

5 June 2018

1 reference

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Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.

5 June 2018

1 reference

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Inhibition of heme crystal growth by antimalarials and other compounds: implications for drug discovery

5 June 2018

1 reference

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COMPLEX FORMATION BETWEEN CHLOROQUINE AND FERRIHAEMIC ACID IN VITRO, AND ITS EFFECT ON THE ANTIMALARIAL ACTION OF CHLOROQUINE.

5 June 2018

1 reference

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Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

5 June 2018

1 reference

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Solution structures of antimalarial drug-heme complexes

5 June 2018

1 reference

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Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position

5 June 2018

1 reference

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Fate of haem iron in the malaria parasite Plasmodium falciparum

5 June 2018

1 reference

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Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Standardization of the physicochemical parameters to assess in vitro the beta-hematin inhibitory activity of antimalarial drugs.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Mechanism of heme degradation by heme oxygenase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

The structure of malaria pigment beta-haematin

5 June 2018

1 reference

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An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

On the molecular mechanism of chloroquine's antimalarial action

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties.

5 June 2018

1 reference

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Plasmodium hemozoin formation mediated by histidine-rich proteins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment).

5 June 2018

1 reference

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Morphological Effects of Chloroquine on Plasmodium berghei in Mice

5 June 2018

1 reference

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A perspective on antimalarial action: effects of weak bases on Plasmodium falciparum

5 June 2018

1 reference

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Human malaria parasites in continuous culture

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Haemozoin (beta-haematin) biomineralization occurs by self-assembly near the lipid/water interface

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Inhibition assay of beta-hematin formation initiated by lecithin for screening new antimalarial drugs

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Spectrophotometric determination of de novo hemozoin/beta-hematin formation in an in vitro assay

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

A physiochemical mechanism of hemozoin (beta-hematin) synthesis by malaria parasite

18 August 2018

1 reference

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In vitro beta-hematin formation assays with plasma of mice infected with Plasmodium yoelii and other parasite preparations: comparative inhibition with quinoline and endoperoxide antimalarials

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

The mechanism of beta-hematin formation in acetate solution. Parallels between hemozoin formation and biomineralization processes

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Assay of beta-hematin formation by malaria parasite

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Involvement of lipids in ferriprotoporphyrin IX polymerization in malaria

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

A colorimetric assay for heme in biological samples using 96-well plates

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

A simple and rapid colorimetric method to measure hemozoin crystal growth in vitro

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3535939

2 December 2018

Identifiers

DOI

10.1128/AAC.01709-12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23114783%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23114783%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PubMed publication ID

23114783

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23114783%20AND%20SRC:MED&resulttype=core&format=json