Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling (Q41956357)

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scientific article published on 23 January 2014

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English	Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling	scientific article published on 23 January 2014

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scholarly article

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Europe PubMed Central

14 October 2017

Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling (English)

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14 October 2017

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2 June 2020

Varman T Samuel

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Varman T Samuel

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W. Mark Saltzman

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Mark Saltzman

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2 June 2020

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Arijeet K Gattu

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Andreas L Birkenfeld

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Yasuko Iwakiri

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Jennifer Doll

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Petr Protiva

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Susan E Crawford

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Chuhan Chung

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2 June 2020

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23 January 2014

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14 October 2017

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155

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2 June 2020

1373-1385

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2 June 2020

Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content

1 reference

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5 June 2018

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

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Genomic responses in mouse models poorly mimic human inflammatory diseases

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Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance

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Wnt/β-catenin signaling and disease

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Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

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Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure

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Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease

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Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1.

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Mutations in SERPINF1 cause osteogenesis imperfecta type VI

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Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

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Identification of a novel inhibitor of the canonical Wnt pathway

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Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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5 June 2018

Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase

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5 June 2018

Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta

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5 June 2018

Wnt signaling regulates hepatic metabolism

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5 June 2018

Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization

1 reference

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5 June 2018

Inflammatory mechanisms in obesity

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5 June 2018

Interleukin-1beta may mediate insulin resistance in liver-derived cells in response to adipocyte inflammation.

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alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population

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Controlled delivery of VEGF via modulation of alginate microparticle ionic crosslinking

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5 June 2018

Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator

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5 June 2018

Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL).

1 reference

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5 June 2018

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

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5 June 2018

Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes

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Anaplerotic roles of pyruvate carboxylase in mammalian tissues

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

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5 June 2018

Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5393334

5 June 2018

Stimulation of neovascularization by the anti-angiogenic factor PEDF.

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5 June 2018

Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization

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5 June 2018

Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

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5 June 2018

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

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5 June 2018

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

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5 June 2018

Pigment epithelium-derived factor: a potent inhibitor of angiogenesis

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5 June 2018

Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin.

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5 June 2018

Superoxide generation by neutrophils and Kupffer cells during in vivo reperfusion after hepatic ischemia in rats

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5 June 2018

Pigment epithelium-derived factor enhances differentiation and mineral deposition of human mesenchymal stem cells.

1 reference

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18 August 2018

Acute metabolic amplification of insulin secretion in mouse islets is mediated by mitochondrial export of metabolites, but not by mitochondrial energy generation

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18 August 2018

Serum levels of pigment epithelium-derived factor (PEDF) are independently associated with procollagen III N-terminal peptide levels in patients with nonalcoholic fatty liver disease.

1 reference

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18 August 2018

Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients

1 reference

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18 August 2018

Pigment epithelium-derived factor increases in type 2 diabetes after treatment with metformin.

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18 August 2018

Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes

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18 August 2018

Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective study.

1 reference

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18 August 2018

Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss

1 reference

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18 August 2018

Pigment epithelium-derived factor contributes to insulin resistance in obesity.

1 reference

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18 August 2018

Identification of Adipocyte Genes Regulated by Caloric Intake

1 reference

https://pubmed.ncbi.nlm.nih.gov/24456163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24456163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of pigment epithelium derived factor on the expression of glutamine synthetase in early phase of experimental diabetic retinopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24456163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated serum levels of pigment epithelium-derived factor in the metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/24456163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of circulating pigment epithelium-derived factor is a marker of osteogenesis imperfecta type VI

1 reference

https://pubmed.ncbi.nlm.nih.gov/24456163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1210/EN.2013-1785

1 reference

Europe PubMed Central

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2 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24456163%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24456163%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

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