ATPase copper transporting beta (Q419611)

P-type ATPase, subfamily IB

1 reference

Heavy metal-associated domain superfamily

1 reference

P-type ATPase, cytoplasmic domain N

1 reference

P-type ATPase, transmembrane domain superfamily

1 reference

HAD-like superfamily

1 reference

Transporter Classification Database ID

P-type ATPase

1 reference

3.A.3.5.3

2 October 2019

hierarchical database ID heuristic

Heavy metal-associated domain, HMA, protein family

1 reference

inferred from protein domain or family

Heavy metal-associated domain, copper ion-binding domain, protein family

1 reference

inferred from protein domain or family

Heavy-metal-associated, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

P-type divalent copper transporter activity

ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

Functional properties of the human copper-transporting ATPase ATP7B (the Wilson's disease protein) and regulation by metallochaperone Atox1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

ATPase-coupled cation transmembrane transporter activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

1 reference

8 April 2019

protein binding

4 references

8 April 2019

Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

A new hepatocytic isoform of PLZF lacking the BTB domain interacts with ATP7B, the Wilson disease protein, and positively regulates ERK signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

copper ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

3 references

8 April 2019

8 April 2019

Metallochaperone Atox1 transfers copper to the NH2-terminal domain of the Wilson's disease protein and regulates its catalytic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

Binding of copper(I) by the Wilson disease protein and its copper chaperone

GOA

curator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35670&geneProductId=UniProtKB:P35670

1 reference

1 January 2018

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

3 references

8 April 2019

8 April 2019

Solution structure of the N-domain of Wilson disease protein: distinct nucleotide-binding environment and effects of disease mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

The distinct functional properties of the nucleotide-binding domain of ATP7B, the human copper-transporting ATPase: analysis of the Wilson disease mutations E1064A, H1069Q, R1151H, and C1104F

GOA

curator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

P-type divalent copper transporter activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35670&geneProductId=UniProtKB:P35670

3 references

17 October 2017

17 October 2017

Functional characterization of missense mutations in ATP7B: Wilson disease mutation or normal variant?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35670&geneProductId=UniProtKB:P35670

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35670&geneProductId=UniProtKB:P35670

copper ion transmembrane transporter activity

1 reference

8 April 2019

Functional characterization of new mutations in Wilson disease gene (ATP7B) using the yeast model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

P-type divalent copper transporter activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

4 references

8 April 2019

8 April 2019

Functional characterization of missense mutations in ATP7B: Wilson disease mutation or normal variant?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

IBA

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

1 reference

8 April 2019

trans-Golgi network membrane

1 reference

8 April 2019

Functional characterization of missense mutations in ATP7B: Wilson disease mutation or normal variant?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35670&geneProductId=UniProtKB:P35670

3 references

17 October 2017

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35670&geneProductId=UniProtKB:P35670

17 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35670&geneProductId=UniProtKB:P35670

integral component of plasma membrane

1 reference

8 April 2019

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

trans-Golgi network

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35670&geneProductId=UniProtKB:P35670

17 October 2017

ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35670&geneProductId=UniProtKB:P35670

17 October 2017

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35670&geneProductId=UniProtKB:P35670

basolateral plasma membrane

1 reference

8 April 2019

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

1 reference

8 April 2019

perinuclear region of cytoplasm

1 reference

17 October 2017

Copper binding to the N-terminal metal-binding sites or the CPC motif is not essential for copper-induced trafficking of the human Wilson protein (ATP7B)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35670&geneProductId=UniProtKB:P35670

endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

1 reference

8 April 2019

cytoplasmic vesicle

1 reference

8 April 2019

ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

trans-Golgi network

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

IBA

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

perinuclear region of cytoplasm

HDA

IBA

protein maturation by copper ion transfer

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

copper ion transmembrane transport

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

metal ion transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

1 reference

8 April 2019

copper ion import

1 reference

8 April 2019

ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

cation transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

1 reference

8 April 2019

ion transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

1 reference

8 April 2019

copper ion export

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

ion transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

1 reference

8 April 2019

sequestering of calcium ion

1 reference

8 April 2019

ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

cellular zinc ion homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

lactation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

response to copper ion

3 references

8 April 2019

Copper binding to the N-terminal metal-binding sites or the CPC motif is not essential for copper-induced trafficking of the human Wilson protein (ATP7B)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

copper ion transport

Functional characterization of missense mutations in ATP7B: Wilson disease mutation or normal variant?

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

IMP

8 April 2019

Copper-induced trafficking of the cU-ATPases: a key mechanism for copper homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

IGI

8 April 2019

Functional characterization of new mutations in Wilson disease gene (ATP7B) using the yeast model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

8 April 2019

Functional characterization of new mutations in Wilson disease gene (ATP7B) using the yeast model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35670

transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35670&geneProductId=UniProtKB:P35670

1 reference

17 October 2017

http://purl.uniprot.org/uniprot/P35670

Gene Atlas image

PBB GE ATP7B 204624 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Identifiers.org

Identifiers

MeSH descriptor ID

C000612464

subject named as

ATP7B protein, human

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1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

1 reference

13 November 2019

1 reference

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1 reference

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1 reference

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28 October 2013

Microsoft Academic ID

0 references

0 references

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

3.A.3.5.3

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023