Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling (Q41976932)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21098033%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling (English)

1 reference

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16 January 2020

1 reference

2

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16 January 2020

Steve P. Watson

8

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16 January 2020

Sonia Séverin

1

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16 January 2020

Leyre Navarro-Nuñez

3

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16 January 2020

Yotis A Senis

7

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16 January 2020

author name string

Craig A Nash

4

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16 January 2020

Diego Mourão-Sá

5

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16 January 2020

Johannes A Eble

6

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16 January 2020

language of work or name

English

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publication date

22 November 2010

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Journal of Biological Chemistry

16 January 2020

published in

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16 January 2020

volume

286

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16 January 2020

issue

6

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16 January 2020

page(s)

4107-4116

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A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function

16 January 2020

cites work

1 reference

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Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

5 June 2018

1 reference

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The SYK tyrosine kinase: a crucial player in diverse biological functions

5 June 2018

1 reference

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Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

5 June 2018

1 reference

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CLEC-2 activates Syk through dimerization

5 June 2018

1 reference

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Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation.

5 June 2018

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Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role

5 June 2018

1 reference

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The platelet receptor CLEC-2 is active as a dimer

5 June 2018

1 reference

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CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils.

5 June 2018

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The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

5 June 2018

1 reference

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G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2

5 June 2018

1 reference

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The crystal structure of the platelet activator aggretin reveals a novel (alphabeta)2 dimeric structure

5 June 2018

1 reference

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Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2

5 June 2018

1 reference

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A mechanism for SRC kinase-dependent signaling by noncatalytic receptors

5 June 2018

1 reference

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Renal cells activate the platelet receptor CLEC-2 through podoplanin

5 June 2018

1 reference

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Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.

5 June 2018

1 reference

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The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis

5 June 2018

1 reference

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The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade

5 June 2018

1 reference

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A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein

5 June 2018

1 reference

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Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

5 June 2018

1 reference

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A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

5 June 2018

1 reference

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Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.

5 June 2018

1 reference

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T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema

5 June 2018

1 reference

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Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling

5 June 2018

1 reference

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A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex

5 June 2018

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Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling

5 June 2018

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Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway

5 June 2018

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Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells

5 June 2018

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Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets

5 June 2018

1 reference

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The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

5 June 2018

1 reference

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CLEC-2 is not required for platelet aggregation at arteriolar shear

5 June 2018

1 reference

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Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac.

18 August 2018

1 reference

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The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.

18 August 2018

1 reference

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Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling.

18 August 2018

1 reference

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Regulated expression of the receptor-like tyrosine phosphatase CD148 on hemopoietic cells

18 August 2018

1 reference

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Identification and activation of Src family kinases in primary megakaryocytes

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039337

Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039337

Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3039337

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21098033

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of the Src family kinases, Lck and Fgr in platelets. Their tyrosine phosphorylation status and subcellular distribution compared with other Src family members

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21098033

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21098033

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.167502

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21098033%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21098033%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference