Hepcidin antimicrobial peptide (Q419983)

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mammalian protein found in Homo sapiens

• hepcidin
• liver-expressed antimicrobial peptide 1
• HAMP
• PLTR
• putative liver tumor regressor
• LEAP-1
• hepcidin preproprotein

edit

Language	Label	Description	Also known as
English	Hepcidin antimicrobial peptide	mammalian protein found in Homo sapiens	hepcidin liver-expressed antimicrobial peptide 1 HAMP PLTR putative liver tumor regressor LEAP-1 hepcidin preproprotein

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P81172

part of

Hepcidins

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P81172

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

8.A.37.1.2

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

image

PDB 1m4f EBI.jpg
800 × 600; 29 KB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P81172

encoded by

HAMP

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P81172

molecular function

hormone activity

determination method

IDA

IEA

3 references

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P81172

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IEA

retrieved

24 April 2018

stated in

Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

retrieved

24 April 2018

stated in

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

iron ion transmembrane transporter inhibitor activity

determination method

IDA

1 reference

retrieved

24 April 2018

stated in

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

signaling receptor binding

determination method

IPI

2 references

retrieved

24 April 2018

stated in

Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IPI

retrieved

24 April 2018

stated in

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IPI

hormone activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P81172

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

cell component

cytoplasm

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

extracellular region

determination method

NAS

IEA

3 references

retrieved

9 May 2019

stated in

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

GOA

curator

UniProt

UniProt protein ID

P81172

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

NAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P81172

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

apical cortex

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

intercalated disc

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

extracellular space

determination method

IBA

IDA

IEA

4 references

retrieved

24 April 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IEA

retrieved

24 April 2018

stated in

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

GOA

curator

UniProt

UniProt protein ID

P81172

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

retrieved

24 April 2018

stated in

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

retrieved

24 April 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IBA

extracellular space

determination method

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IBA

biological process

negative regulation of iron export across plasma membrane

determination method

IDA

1 reference

retrieved

24 April 2018

stated in

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

negative regulation of intestinal absorption

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IMP

positive regulation of receptor internalization

determination method

IDA

1 reference

retrieved

24 April 2018

stated in

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

negative regulation of transcription by RNA polymerase II

determination method

ISS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

ISS

negative regulation of iron ion transmembrane transporter activity

determination method

IDA

1 reference

retrieved

24 April 2018

stated in

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

response to iron ion

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IMP

multicellular organismal iron ion homeostasis

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IMP

defense response to bacterium

determination method

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P81172

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IBA

immune response

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

GOA

curator

UniProt

UniProt protein ID

P81172

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

TAS

positive regulation of receptor catabolic process

determination method

IDA

1 reference

retrieved

24 April 2018

stated in

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

positive regulation of protein polyubiquitination

determination method

IDA

1 reference

retrieved

24 April 2018

stated in

Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

negative regulation of ion transmembrane transporter activity

determination method

IDA

1 reference

retrieved

24 April 2018

stated in

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

cellular iron ion homeostasis

determination method

IDA

IEA

4 references

retrieved

24 April 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IEA

retrieved

24 April 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IEA

retrieved

24 April 2018

stated in

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

retrieved

24 April 2018

stated in

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

cellular response to lipopolysaccharide

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

human ageing

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

cellular response to tumor necrosis factor

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

liver regeneration

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

cellular response to bile acid

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

cellular response to interleukin-6

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

response to iron ion starvation

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

response to vitamin A

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

response to erythropoietin

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

positive regulation of cell growth involved in cardiac muscle cell development

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

response to ethanol

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

acute-phase response

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

cellular response to X-ray

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

response to zinc ion

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

negative regulation of iron ion transmembrane transport

determination method

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IBA

antimicrobial humoral immune response mediated by antimicrobial peptide

determination method

IDA

2 references

retrieved

24 April 2018

stated in

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

GOA

curator

UniProt

UniProt protein ID

P81172

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

retrieved

24 April 2018

stated in

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

GOA

curator

UniProt

UniProt protein ID

P81172

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P81172&geneProductId=UniProtKB:P81172

determination method

IDA

killing of cells of other organism

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P81172

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

defense response to fungus

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P81172

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

regulation of signaling receptor activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

cellular iron ion homeostasis

determination method

IBA

IDA

IEA

4 references

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

retrieved

9 May 2019

stated in

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IBA

signal transduction

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81172

determination method

IEA

manufacturer

liver

0 references

Gene Atlas image

PBB GE HAMP 220491 at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P81172

1 reference

stated in

Identifiers.org

Commons category

Hepcidin

0 references

Identifiers

RefSeq protein ID

NP_066998

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

57817

UniProt protein ID

P81172

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P81172

Ensembl protein ID

ENSP00000222304

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000222304

ENSP00000471894

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000471894

Freebase ID

/m/09795k

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

PDB structure ID

1M4E

1 reference

stated in

UniProt

UniProt protein ID

P81172

retrieved

9 August 2016

language of work or name

English

1M4F

1 reference

stated in

UniProt

UniProt protein ID

P81172

retrieved

9 August 2016

language of work or name

English

2KEF

1 reference

stated in

UniProt

UniProt protein ID

P81172

retrieved

9 August 2016

language of work or name

English

3H0T

1 reference

stated in

UniProt

UniProt protein ID

P81172

retrieved

9 August 2016

language of work or name

English

4QAE

1 reference

stated in

UniProt

UniProt protein ID

P81172

retrieved

9 August 2016

language of work or name

English

Transporter Classification Database ID

8.A.37.1.2

2 references

stated in

Transporter Classification database

retrieved

13 March 2020

stated in

Transporter Classification database

retrieved

29 April 2020

 

Sitelinks

Wikipedia(17 entries)

edit

• arwiki HAMP
• bswiki HAMP
• cswiki Hepcidin
• cywiki HAMP
• dewiki Hepcidin
• enwiki HAMP
• eswiki Hepcidina
• fawiki هپسیدین
• frwiki Hepcidine
• glwiki Hepcidina
• hrwiki Hepcidin
• itwiki Epcidina
• nlwiki Hepcidine
• plwiki Hepcydyna
• ptwiki Hepcidina
• ukwiki Гепсидин
• zhwiki 铁调素

Wikibooks(0 entries)

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Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(1 entry)

edit

• commonswiki Category:Hepcidin

Retrieved from "https://www.wikidata.org/w/index.php?title=Q419983&oldid=2073637994"