KIR2DL5: An Orphan Inhibitory Receptor Displaying Complex Patterns of Polymorphism and Expression. (Q42006517)

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10 March 2020

title

KIR2DL5: An Orphan Inhibitory Receptor Displaying Complex Patterns of Polymorphism and Expression (English)

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10 March 2020

4

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10 March 2020

Carlos Vilches

5

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10 March 2020

author name string

Elisa Cisneros

1

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10 March 2020

Manuela Moraru

2

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10 March 2020

Natalia Gómez-Lozano

3

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10 March 2020

publication date

17 September 2012

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10 March 2020

published in

Frontiers in Immunology

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10 March 2020

volume

3

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10 March 2020

page(s)

289

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KIR2DL4 (CD158d): An activation receptor for HLA-G.

10 March 2020

cites work

1 reference

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Differential transcription factor use by the KIR2DL4 promoter under constitutive and IL-2/15-treated conditions

5 June 2018

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Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules

5 June 2018

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Conserved KIR allele-level haplotypes are altered by microvariation in individuals with European ancestry

5 June 2018

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Killer immunoglobulin-like receptor transcriptional regulation: a fascinating dance of multiple promoters.

5 June 2018

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Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus

5 June 2018

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Evolutionary patterns of killer cell Ig-like receptor genes in Old World monkeys

5 June 2018

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5 June 2018

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Endosomal Signaling and a Novel Pathway Defined by the Natural Killer Receptor KIR2DL4 (CD158d)

5 June 2018

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Thirty allele-level haplotypes centered around KIR2DL5 define the diversity in an African American population

5 June 2018

1 reference

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A small, variable, and irregular killer cell Ig-like receptor locus accompanies the absence of MHC-C and MHC-G in gibbons

5 June 2018

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IPD--the Immuno Polymorphism Database

5 June 2018

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Genetic control of variegated KIR gene expression: polymorphisms of the bi-directional KIR3DL1 promoter are associated with distinct frequencies of gene expression

5 June 2018

1 reference

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Complete characterization of killer Ig-like receptor (KIR) haplotypes in Mauritian cynomolgus macaques: novel insights into nonhuman primate KIR gene content and organization

5 June 2018

1 reference

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Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5.

5 June 2018

1 reference

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High-throughput killer cell immunoglobulin-like receptor genotyping by MALDI-TOF mass spectrometry with discovery of novel alleles

5 June 2018

1 reference

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Identification of bidirectional promoters in the human KIR genes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443818

Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3.

5 June 2018

1 reference

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Single haplotype analysis demonstrates rapid evolution of the killer immunoglobulin-like receptor (KIR) loci in primates

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443818

KIR2DL5 can inhibit human NK cell activation via recruitment of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2).

5 June 2018

1 reference

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Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors

5 June 2018

1 reference

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Recognition of HLA-G by the NK cell receptor KIR2DL4 is not essential for human reproduction

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443818

DNA methylation maintains allele-specific KIR gene expression in human natural killer cells

5 June 2018

1 reference

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Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells

5 June 2018

1 reference

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KIR: diverse, rapidly evolving receptors of innate and adaptive immunity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443818

Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene

5 June 2018

1 reference

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Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans

5 June 2018

1 reference

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KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains.

5 June 2018

1 reference

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Plasticity in the organization and sequences of human KIR/ILT gene families

5 June 2018

1 reference

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Codon usage tabulated from international DNA sequence databases: status for the year 2000

5 June 2018

1 reference

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Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.

5 June 2018

1 reference

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KIR2DL5 alleles mark certain combination of activating KIR genes

17 August 2018

1 reference

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Polymorphisms of KIRs gene and HLA-C alleles in patients with ankylosing spondylitis: possible association with susceptibility to the disease

17 August 2018

1 reference

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Epigenetic silencing of potentially functional KIR2DL5 alleles: Implications for the acquisition of KIR repertoires by NK cells.

17 August 2018

1 reference

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Cutting edge: KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein

17 August 2018

1 reference

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Killer cell immunoglobulin-like receptors (KIR) of the African-origin sabaeus monkey: evidence for recombination events in the evolution of KIR.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443818

The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443818

Cutting edge: expansion of the KIR locus by unequal crossing over

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443818

Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443818

Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443818

Diversity of the killer cell Ig-like receptors of rhesus monkeys

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443818

Promoter variants of KIR2DL5 add to diversity and may impact gene expression

17 August 2018

1 reference

12 December 2020

Structural and functional differences between the promoters of independently expressed killer cell Ig-like receptors

1 reference

12 December 2020

Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets

1 reference

12 December 2020

Genotyping of human killer-cell immunoglobulin-like receptor genes by polymerase chain reaction with sequence-specific primers: an update

1 reference

12 December 2020

Molecular characterisation of KIR2DS2*005, a fusion gene associated with a shortened KIR haplotype

1 reference

12 December 2020

Activating KIR genes are associated with ankylosing spondylitis in Asian populations

1 reference

12 December 2020

Functional redundancy of transcription factor-binding sites in the killer cell Ig-like receptor (KIR) gene promoter

1 reference

12 December 2020

Duplication, mutation and recombination of the human orphan gene KIR2DS3 contribute to the diversity of KIR haplotypes

1 reference

12 December 2020

Killer immunoglobulin receptor gene and allele frequencies in Caucasoid, Oriental and Black populations from different continents

1 reference

12 December 2020

Identifiers

DOI

10.3389/FIMMU.2012.00289

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23060877%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23060877%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

PubMed publication ID

23060877

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23060877%20AND%20SRC:MED&resulttype=core&format=json