Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis. (Q42006595)

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English	Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis.	scientific article

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scholarly article

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11 November 2019

Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis (English)

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11 November 2019

connective tissue

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based on heuristic

inferred from title

pulmonary fibrosis

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based on heuristic

inferred from title

Robin J McAnulty

4

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11 November 2019

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D C Howell

1

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11 November 2019

N R Goldsack

2

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11 November 2019

R P Marshall

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11 November 2019

R Starke

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11 November 2019

G Purdy

6

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11 November 2019

G J Laurent

7

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11 November 2019

R C Chambers

8

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11 November 2019

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1 October 2001

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11 November 2019

The American Journal of Pathology

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11 November 2019

159

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11 November 2019

4

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11 November 2019

1383-1395

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11 November 2019

Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice.

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5 June 2018

A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice

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5 June 2018

Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1.

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5 June 2018

Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis

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Bronchoconstrictor effect of thrombin and thrombin receptor activating peptide in guinea-pigs in vivo

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5 June 2018

Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis

1 reference

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Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.

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5 June 2018

Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1

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5 June 2018

Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts

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5 June 2018

Thrombin receptor antagonists: a work in progress.

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5 June 2018

Thrombin inhibitors reduce intrapulmonary accumulation of fibrinogen and procoagulant activity of bronchoalveolar lavage fluid during acute lung injury induced by pulmonary overdistention in newborn piglets

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5 June 2018

Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene

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5 June 2018

Characterization of the receptor responsible for thrombin-induced intracellular calcium responses in osteoblast-like cells.

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5 June 2018

Thrombin stimulates fibroblast chemotaxis and replication

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5 June 2018

Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin.

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5 June 2018

Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet-derived growth factor alpha-receptor

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5 June 2018

Chemotactic response of monocytes to thrombin

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5 June 2018

Assembly of the prothrombin activator complex on rabbit alveolar macrophage high-affinity factor Xa receptors. A kinetic study

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5 June 2018

Abnormalities of pathways of fibrin turnover in lung lavage of rats with oleic acid and bleomycin-induced lung injury support alveolar fibrin deposition

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5 June 2018

Profiles of steady state levels of messenger RNAs coding for type I procollagen, elastin, and fibronectin in hamster lungs undergoing bleomycin-induced interstitial pulmonary fibrosis

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5 June 2018

Effect of recombinant hirudin, a specific inhibitor of thrombin, on endotoxin-induced intravascular coagulation and acute lung injury in pigs

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5 June 2018

Thrombin immobilized to extracellular matrix is a potent mitogen for vascular smooth muscle cells: nonenzymatic mode of action

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5 June 2018

Mechanisms of bleomycin-induced lung damage

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5 June 2018

Procoagulant activity of alveolar macrophages in bleomycin-induced lung fibrosis in rats

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5 June 2018

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

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5 June 2018

Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion

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5 June 2018

Thrombin receptor expression in normal and atherosclerotic human arteries

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5 June 2018

Mitogenic activity of blood components. I. Thrombin and prothrombin

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5 June 2018

Thrombin and fibrin-induced growth of fibroblasts: Role in wound repair and thrombus organization

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Heparin improves gas exchange during experimental acute lung injury in newborn piglets

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The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice

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A rapid and convenient assay for counting cells cultured in microwell plates: application for assessment of growth factors.

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17 August 2018

Plasmin Desensitization of the PAR1 Thrombin Receptor: Kinetics, Sites of Truncation, and Implications for Thrombolytic Therapy†

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2 December 2018

Increased procoagulant and antifibrinolytic activities in the lungs with idiopathic pulmonary fibrosis

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7 January 2021

Procoagulant activity in bronchoalveolar lavage in the adult respiratory distress syndrome. Contribution of tissue factor associated with factor VII

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Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis

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Role of thrombin in pulmonary fibrosis

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7 January 2021

Thrombin Enhances Lung Fibroblast Proliferation in Bleomycin-induced Pulmonary Fibrosis

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Decreased protein C activation is associated with abnormal collagen turnover in the intraalveolar space of patients with interstitial lung disease

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Antithrombin III (AT III) prevents LPS-induced pulmonary vascular injury: novel biological activity of AT III

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7 January 2021

Heparin attenuates bleomycin but not silica-induced pulmonary fibrosis in mice: possible relationship with involvement of myofibroblasts in bleomycin, and fibroblasts in silica-induced fibrosis

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Thrombin-induced chemotaxis and aggregation of neutrophils

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Cell surface action of thrombin is sufficient to initiate division of chick cells

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Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor

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Enhanced insulin-like growth factor binding protein-related protein 2 (Connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis

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7 January 2021

Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in rats

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7 January 2021

Application of high-pressure liquid chromatography to studies of collagen production by isolated cells in culture

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A simplified method for quantitation of the relative amounts of type I and type III collagen in small tissue samples

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7 January 2021

Thrombin-elicited contractile responses of aortic smooth muscle

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7 January 2021

Release and activation of platelet latent TGF–β in blood clots during dissolution with plasmin

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7 January 2021

Monocyte chemotaxis: stimulation by specific exosite region in thrombin

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Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells

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Thrombin in the airways of asthmatic patients

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Development of potent thrombin receptor antagonist peptides

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7 January 2021

The role of thrombin on lung fibroblast growth and fibrosis in bleomycin-induced lung disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cadmium selectively inhibits fibroblast procollagen production and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Fibrin deposition and fibrinolysis in the pathogenesis of pulmonary fibrosis]

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrinolysis inhibition in acute respiratory distress syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue factor and factor VII messenger RNAs in human alveolar macrophages: effects of breathing ozone

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular localization of enzymatically active thrombin in intact human tissues by hirudin binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between thrombin-induced prostacyclin production and inositol trisphosphate and cytosolic free calcium levels in cultured human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth factor activity in the lung during compensatory growth after pneumonectomy: evidence of a role for IGF-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-mediated chemotactic response of a macrophage cell line (J774) to thrombin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of lung fibrosis and potential new therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombin stimulates platelet-derived growth factor release by alveolar macrophages in rats--significance in bleomycin-induced pulmonary fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural alterations of lung parenchyma in the adult respiratory distress syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11583966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/S0002-9440(10)62525-4

1 reference

Europe PubMed Central

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11 November 2019

1 reference

Europe PubMed Central

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11 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11583966%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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