The role of lipophilicity in the inhibition of polymorphic cytochrome P450IID6 oxidation by beta-blocking agents in vitro (Q42006706)

15 October 2017

The role of lipophilicity in the inhibition of polymorphic cytochrome P450IID6 oxidation by beta-blocking agents in vitro (English)

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

cytochrome P-450 enzyme inhibitors

26 October 2022

main subject

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1675413

26 October 2022

1

S. Ferrari

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1675413

26 October 2022

author name string

T. Leemann

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1675413

26 October 2022

P. Dayer

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1675413

26 October 2022

language of work or name

English

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publication date

1 January 1991

1 reference

full work available at URL

15 October 2017

https://api.elsevier.com/content/article/PII:0024320591903418?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

https://api.elsevier.com/content/article/PII:0024320591903418?httpAccept=text/plain

26 October 2022

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

26 October 2022

1 reference

15 October 2017

48

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15 October 2017

23

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15 October 2017

2259-2265

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Quantitative structure-pharmacokinetic relationships and drug design

15 October 2017

2

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

The clinical importance of cardioselectivity and lipophilicity in beta blockers.

26 October 2022

4

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Quantitative relationships between structure and pharmacokinetics of beta-adrenoceptor blocking agents in man

26 October 2022

5

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

The polymorphic oxidation of beta-adrenoceptor antagonists. Clinical pharmacokinetic considerations

26 October 2022

6

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Interindividual variation of beta-adrenoceptor blocking drugs, plasma concentration and effect: influence of genetic status on behaviour of atenolol, bopindolol and metoprolol

26 October 2022

7

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Interindividual pharmacokinetic and pharmacodynamic variability of different beta blockers

26 October 2022

8

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

The polymorphic oxidation of beta-adrenoceptor antagonists

26 October 2022

9

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci

26 October 2022

10

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers

26 October 2022

11

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation

26 October 2022

12

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

26 October 2022

13

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db1 activity

26 October 2022

14

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

An investigation of the comparative liposolubilities of β-adrenoceptor blocking agents

26 October 2022

15

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Inhibition of synaptosomal [3H]noradrenaline uptake by β-adrenoceptor blocking drugs: Influence of lipophilicity

26 October 2022

16

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Dependence of hydrogen peroxide formation in rat liver microsomes on the molecular structure of cytochrome P-450 substrates: a study with barbiturates and beta-adrenoceptor antagonists

26 October 2022

17

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Inhibition of lignocaine metabolism by beta-adrenoceptor antagonists in rat and human liver microsomes

26 October 2022

18

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation. Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency

26 October 2022

20

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Protein measurement with the Folin phenol reagent

26 October 2022

21

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

The Determination of Enzyme Dissociation Constants

26 October 2022

24

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Selection of a Reference Partitioning System for Drug Design Work

26 October 2022

26

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Some advantages of calculating octanol-water partition coefficients

26 October 2022

27

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Prediction of hepatic first-pass metabolism and plasma levels following intravenous and oral administration of barbiturates in the rabbit based on quantitative structure-pharmacokinetic relationships.

26 October 2022

28

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Inhibition of oxidative drug metabolism by beta-adrenoceptor antagonists in related to their lipid solubility [letter]

26 October 2022

29

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Inhibition of antipyrine metabolism by beta-adrenoceptor antagonists

26 October 2022

30

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Comparison of beta-adrenoceptor antagonists as modulators of drug metabolism: effect of lipophilicity on microsomal phase I and II reactions

26 October 2022

31

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Interaction of a series of β-adrenergic blocking drugs with rat hepatic microsomal monooxygenase

26 October 2022

32

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs

26 October 2022

33

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Inhibition of tolbutamide metabolism by substituted imidazole drugs in vivo: evidence for a structure-activity relationship

26 October 2022

34

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol

26 October 2022

35

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation. Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency

26 October 2022

36

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

Bioactivation of the narcotic drug codeine in human liver is mediated by the polymorphic monooxygenase catalyzing debrisoquine 4-hydroxylation (cytochrome P-450 dbl/bufI)

26 October 2022

37

1 reference

https://api.crossref.org/works/10.1016/0024-3205(91)90341-8

26 October 2022

Identifiers

1 reference

15 October 2017

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