Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins. (Q42024219)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688021%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688021%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688021%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Peter M Glazer

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688021%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

Susan E Scanlon

series ordinal

1

1 reference

15 October 2017

Peter M Glazer

series ordinal

2

1 reference

15 October 2017

31 March 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688021%20AND%20SRC:MED&resulttype=core&format=json

Molecular Cancer Research

12 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688021%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

volume

12

1 reference

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12 March 2020

issue

7

1 reference

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12 March 2020

page(s)

1016-1028

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688021%20AND%20SRC:MED&resulttype=core&format=json

The comet assay, DNA damage, DNA repair and cytotoxicity: hedgehogs are not always dead

12 March 2020

cites work

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5 June 2018

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A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

5 June 2018

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Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

5 June 2018

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Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

5 June 2018

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Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

5 June 2018

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5 June 2018

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Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability

5 June 2018

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New aspects on chromosomal instability: chromosomal break-points in Fanconi anemia patients co-localize on the molecular level with fragile sites

5 June 2018

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FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL

5 June 2018

1 reference

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Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.

5 June 2018

1 reference

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Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

5 June 2018

1 reference

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ATM activation and signaling under hypoxic conditions.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Fanconi anemia proteins stabilize replication forks

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24.

5 June 2018

1 reference

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5 June 2018

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Mutation as a stress response and the regulation of evolvability

5 June 2018

1 reference

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Hypoxia in cancer: significance and impact on clinical outcome

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Regulation of DNA repair in hypoxic cancer cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

CHK2-dependent phosphorylation of BRCA1 in hypoxia

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Hypoxia-induced down-regulation of BRCA1 expression by E2Fs.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

ATR couples FANCD2 monoubiquitination to the DNA-damage response

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Oxygen sensing by HIF hydroxylases

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

The human genome browser at UCSC

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Hypoxia links ATR and p53 through replication arrest

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Genetic instability induced by the tumor microenvironment.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101147

Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest

17 August 2018

1 reference

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Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24688021

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1541-7786.MCR-13-0628

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688021%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24688021%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference