Ile115Leu mutation in the SRS1 region of an insect cytochrome P450 (CYP6B1) compromises substrate turnover via changes in a predicted product release channel (Q42041436)

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scientific article published on 18 April 2005

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English	Ile115Leu mutation in the SRS1 region of an insect cytochrome P450 (CYP6B1) compromises substrate turnover via changes in a predicted product release channel	scientific article published on 18 April 2005

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

15 October 2017

Ile115Leu mutation in the SRS1 region of an insect cytochrome P450 (CYP6B1) compromises substrate turnover via changes in a predicted product release channel (English)

1 reference

Europe PubMed Central

PubMed publication ID

15 October 2017

0 references

May R. Berenbaum

3

object named as

May R Berenbaum

1 reference

Europe PubMed Central

PubMed publication ID

15 October 2017

Mary A. Schuler

4

object named as

Mary A Schuler

1 reference

Europe PubMed Central

PubMed publication ID

15 October 2017

2

object named as

Jerome Baudry

1 reference

Europe PubMed Central

PubMed publication ID

15 October 2017

1

object named as

Zhimou Wen

1 reference

Europe PubMed Central

PubMed publication ID

15 October 2017

publication date

18 April 2005

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Europe PubMed Central

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15 October 2017

Protein Engineering Design and Selection

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Europe PubMed Central

PubMed publication ID

15 October 2017

18

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Europe PubMed Central

PubMed publication ID

15 October 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

15 October 2017

191-199

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Europe PubMed Central

PubMed publication ID

15 October 2017

Molecular docking of substrates and inhibitors in the catalytic site of CYP6B1, an insect cytochrome p450 monooxygenase

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Nonsubstrate recognition site residues are involved in testosterone hydroxylation by cytochrome P450 CYP 2C11.

1 reference

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21 January 2018

Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase.

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Amino acids in SRS1 and SRS6 are critical for furanocoumarin metabolism by CYP6B1v1, a cytochrome P450 monooxygenase

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation.

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Insect P450 enzymes.

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1

1 reference

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21 January 2018

Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Functional interaction of cytochrome P450 with its redox partners: a critical assessment and update of the topology of predicted contact regions

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

The importance of residues in substrate recognition site 3 for the catalytic function of CYP2D25 (vitamin D 25-hydroxylase).

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

CYP6B3: a second furanocoumarin-inducible cytochrome P450 expressed in Papilio polyxenes

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Isolation and characterization of CYP6B4, a furanocoumarin-inducible cytochrome P450 from a polyphagous caterpillar (Lepidoptera: Papilionidae)

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Steered molecular dynamics investigations of protein function.

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

27 Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Specificity and substrate encounter rate

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Molecular cloning and expression of CYP6B8: a xanthotoxin-inducible cytochrome P450 cDNA from Helicoverpa zea

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Structural and functional divergence of insect CYP6B proteins: From specialist to generalist cytochrome P450

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Black swallowtail (Papilio polyxenes) alleles encode cytochrome P450s that selectively metabolize linear furanocoumarins

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

The roles of individual amino acids in altering substrate specificity of the P450 2a4/2a5 enzymes

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Cytochrome P450 and the individuality of species

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Concise review of the cytochrome P450s and their roles in toxicology

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Identification of variable amino acids in the SRS1 region of CYP6B1 modulating furanocoumarin metabolism

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

The importance of SRS-1 residues in catalytic specificity of human cytochrome P450 3A4.

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Cytochromes P450 of insects: the tip of the iceberg

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Site-Directed Mutagenesis as a Tool for Molecular Modeling of Cytochrome P450 2B1

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Metabolism of linear and angular furanocoumarins by Papilio polyxenes CYP6B1 co-expressed with NADPH cytochrome P450 reductase

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Influence of P450 3A4 SRS-2 residues on cooperativity and/or regioselectivity of aflatoxin B(1) oxidation.

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZI023

21 January 2018

Identifiers

10.1093/PROTEIN/GZI023

1 reference

Europe PubMed Central

PubMed publication ID

15 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 October 2017

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