Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins (Q42052555)

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scientific article published on January 2006

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English	Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins	scientific article published on January 2006

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scholarly article

1 reference

Europe PubMed Central

15 October 2017

Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins (English)

1 reference

Europe PubMed Central

15 October 2017

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11

object named as

Markus F Neurath

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Europe PubMed Central

15 October 2017

author name string

Daniela Poppe

1

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Europe PubMed Central

15 October 2017

Imke Tiede

2

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Europe PubMed Central

15 October 2017

Gerhard Fritz

3

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Europe PubMed Central

15 October 2017

Christoph Becker

4

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Europe PubMed Central

15 October 2017

Brigitte Bartsch

5

1 reference

Europe PubMed Central

15 October 2017

Stefan Wirtz

6

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Europe PubMed Central

15 October 2017

Dennis Strand

7

1 reference

Europe PubMed Central

15 October 2017

Shinya Tanaka

8

1 reference

Europe PubMed Central

15 October 2017

Peter R Galle

9

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Europe PubMed Central

15 October 2017

Xosé R Bustelo

10

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Europe PubMed Central

15 October 2017

language of work or name

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publication date

1 January 2006

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Europe PubMed Central

15 October 2017

Journal of Immunology

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Europe PubMed Central

15 October 2017

176

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Europe PubMed Central

15 October 2017

1

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Europe PubMed Central

15 October 2017

640-651

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Europe PubMed Central

15 October 2017

Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial

1 reference

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5 June 2018

Microbial-gut interactions in health and disease. Immune responses

1 reference

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5 June 2018

Peripheral blood mononuclear cell DNA 6-thioguanine metabolite levels correlate with decreased interferon-gamma production in patients with Crohn's disease on AZA therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Differential regulation of TCR-mediated gene transcription by Vav family members

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

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Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

1 reference

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5 June 2018

Vav proteins, masters of the world of cytoskeleton organization.

1 reference

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Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

1 reference

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The immunological and genetic basis of inflammatory bowel disease

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RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

1 reference

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Structural basis for the signaling specificity of RhoG and Rac1 GTPases

1 reference

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Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

1 reference

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5 June 2018

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Azathioprine: old drug, new actions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Vav1: a key signal transducer downstream of the TCR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Vav-1 and the IKK alpha subunit of I kappa B kinase functionally associate to induce NF-kappa B activation in response to CD28 engagement.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Control of T lymphocyte morphology by the GTPase Rho.

1 reference

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5 June 2018

The immunological synapse: integrins take the stage.

1 reference

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5 June 2018

Knocked out by Rho/Rac T-cell biology

1 reference

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5 June 2018

VAV proteins as signal integrators for multi-subunit immune-recognition receptors

1 reference

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5 June 2018

The role of Th1/Th2 polarization in mucosal immunity

1 reference

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5 June 2018

The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Suppression of Ras-induced apoptosis by the Rac GTPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease

1 reference

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5 June 2018

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1 reference

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A controlled double blind study of azathioprine in the management of Crohn's disease

1 reference

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Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1 reference

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Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

1 reference

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5 June 2018

Interleukin-2 induces tyrosine phosphorylation of the vav proto-oncogene product in human T cells: lack of requirement for the tyrosine kinase lck.

1 reference

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Antibodies to interleukin 12 abrogate established experimental colitis in mice

1 reference

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5 June 2018

Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

5 June 2018

Effect of azathioprine and cytosine arabinoside on humoral and cellular immunity in vitro

1 reference

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Effects of azathioprine therapy on bone marrow-dependent and thymus-dependent cells in man.

1 reference

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Effect of Y-27632 on release of cytokines from peripheral T cells in asthmatic patients and normal subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

17 August 2018

CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc42 in human T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

17 August 2018

Differential Control of Cell Cycle, Proliferation, and Survival of Primary T Lymphocytes by Purine and Pyrimidine Nucleotides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

17 August 2018

Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

17 August 2018

The George Hitchings and Gertrude Elion Lecture. The pharmacology of azathioprine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1965586

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1 reference

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Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

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based on heuristic

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ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ten-year results of renal transplantation with azathioprine and prednisolone as only immunosuppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

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based on heuristic

inferred from PubMed ID database lookup

Double-masked trial of azathioprine in multiple sclerosis. British and Dutch Multiple Sclerosis Azathioprine Trial Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of 6-thioguanine in peripheral blood leukocyte DNA in Crohn's disease patients on maintenance 6-mercaptopurine therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

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based on heuristic

inferred from PubMed ID database lookup

The treatment of chronic ulcerative colitis with 6-mercaptopurine

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Azathioprine for maintenance of remission in Crohn's disease: benefits outweigh the risk of lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

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based on heuristic

inferred from PubMed ID database lookup

Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation

1 reference

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inferred from PubMed ID database lookup

Control of pre-T cell proliferation and differentiation by the GTPase Rac-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

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Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

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based on heuristic

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The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

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inferred from PubMed ID database lookup

CD28 Signaling via VAV/SLP-76 Adaptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16365460

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inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.176.1.640

1 reference

Europe PubMed Central

15 October 2017

1 reference

Europe PubMed Central

15 October 2017

1 reference

Europe PubMed Central

15 October 2017

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