Combined genetic and pharmacological inhibition of TRPV1 and P2X3 attenuates colorectal hypersensitivity and afferent sensitization (Q42053717)

15 October 2017

Combined genetic and pharmacological inhibition of TRPV1 and P2X3 attenuates colorectal hypersensitivity and afferent sensitization (English)

1 reference

15 October 2017

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Michael E Kiyatkin

1

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15 October 2017

Bin Feng

series ordinal

2

1 reference

15 October 2017

Erica S Schwartz

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3

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15 October 2017

G F Gebhart

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4

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15 October 2017

29 August 2013

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American Journal of Physiology - Gastrointestinal and Liver Physiology

15 October 2017

1 reference

15 October 2017

305

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15 October 2017

9

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15 October 2017

G638-48

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describes a project that uses

15 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3840237/fullTextXML

inferred from PubMed Central ID database lookup

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5 June 2018

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Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain

5 June 2018

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5 June 2018

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The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis

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5 June 2018

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5 June 2018

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Ca2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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Effects of the somatostatin analogue octreotide on rectal afferent nerves in humans

5 June 2018

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Heightened visceral sensation in functional gastrointestinal disease is not site-specific. Evidence for a generalized disorder of gut sensitivity

5 June 2018

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Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome

5 June 2018

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5 June 2018

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TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation

17 August 2018

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Role of TRPV1 in high-threshold rat colonic splanchnic afferents is revealed by inflammation.

17 August 2018

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Cross-inhibition between native and recombinant TRPV1 and P2X(3) receptors

17 August 2018

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Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats

17 August 2018

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TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats.

17 August 2018

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P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity

17 August 2018

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17 August 2018

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An intracellular motif of P2X(3) receptors is required for functional cross-talk with GABA(A) receptors in nociceptive DRG neurons.

17 August 2018

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The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3.

17 August 2018

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Intrarectal lidocaine is an effective treatment for abdominal pain associated with diarrhea-predominant irritable bowel syndrome

17 August 2018

1 reference

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Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice.

17 August 2018

1 reference

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Characterization of the primary spinal afferent innervation of the mouse colon using retrograde labelling

17 August 2018

1 reference

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Ca2+/calmodulin modulates TRPV1 activation by capsaicin.

17 August 2018

1 reference

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Purinergic mechanisms contribute to mechanosensory transduction in the rat colorectum

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3840237

Reversal of visceral and cutaneous hyperalgesia by local rectal anesthesia in irritable bowel syndrome (IBS) patients

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3840237

Rectal intraganglionic laminar endings are transduction sites of extrinsic mechanoreceptors in the guinea pig rectum.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3840237

TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal neurons from rat.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3840237

The treatment of functional dyspepsia with red pepper

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3840237

A role for calcineurin in the desensitization of the P2X3 receptor

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3840237

Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3840237

Altered rectal perception is a biological marker of patients with irritable bowel syndrome.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3840237

Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds

17 August 2018

1 reference

12 December 2020

Short-term sensitization of colon mechanoreceptors is associated with long-term hypersensitivity to colon distention in the mouse

1 reference

12 December 2020

Evidence for thoracolumbar spinal cord processing of inflammatory, but not acute colonic pain

1 reference

12 December 2020

Intracellular calcium regulation among subpopulations of rat dorsal root ganglion neurons

1 reference

12 December 2020

Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats

1 reference

12 December 2020

Differences in spinal distribution and neurochemical phenotype of colonic afferents in mouse and rat

1 reference

12 December 2020

P2X receptors-mediated cytosolic phospholipase A2 activation in primary afferent sensory neurons contributes to neuropathic pain

1 reference

12 December 2020

Identifiers

DOI

10.1152/AJPGI.00180.2013

1 reference

15 October 2017

1 reference

15 October 2017

PubMed publication ID

23989007

1 reference