Overcoming preexisting humoral immunity to AAV using capsid decoys (Q42056009)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23863832%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Overcoming preexisting humoral immunity to AAV using capsid decoys (English)

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5 March 2020

2

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Katherine A. High

17

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5 March 2020

author name string

Federico Mingozzi

1

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Giulia Pavani

3

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Yifeng Chen

4

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5 March 2020

Robert J Davidson

5

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5 March 2020

Daniel J Hui

6

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Mustafa Yazicioglu

7

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Liron Elkouby

8

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Christian J Hinderer

9

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Armida Faella

10

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Carolann Howard

11

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5 March 2020

Alex Tai

12

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Gregory M Podsakoff

13

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Shangzhen Zhou

14

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Etiena Basner-Tschakarjan

15

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John Fraser Wright

16

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5 March 2020

language of work or name

English

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publication date

1 July 2013

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Science Translational Medicine

5 March 2020

published in

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5 March 2020

volume

5

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page(s)

194ra92

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issue

194

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Minimizing the inhibitory effect of neutralizing antibody for efficient gene expression in the liver with adeno-associated virus 8 vectors.

5 March 2020

cites work

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Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue

5 June 2018

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Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B.

5 June 2018

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Immune tolerance induction in patients with severe hemophilia with inhibitors: expert panel views and recommendations for clinical practice.

5 June 2018

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Adenovirus-associated virus vector-mediated gene transfer in hemophilia B

5 June 2018

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Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity

5 June 2018

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In vivo genome editing restores haemostasis in a mouse model of haemophilia

5 June 2018

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A 10 patient case report on the impact of plasmapheresis upon neutralizing factors against adeno-associated virus (AAV) types 1, 2, 6, and 8.

5 June 2018

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Immune responses to AAV in clinical trials

5 June 2018

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Good manufacturing practice production of self-complementary serotype 8 adeno-associated viral vector for a hemophilia B clinical trial

5 June 2018

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Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins.

5 June 2018

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Preexisting immunity and low expression in primates highlight translational challenges for liver-directed AAV8-mediated gene therapy

5 June 2018

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Peripheral transvenular delivery of adeno-associated viral vectors to skeletal muscle as a novel therapy for hemophilia B.

5 June 2018

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Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction.

5 June 2018

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Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors

5 June 2018

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Safety and efficacy of gene transfer for Leber's congenital amaurosis

5 June 2018

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Manufacturing and characterizing AAV-based vectors for use in clinical studies

5 June 2018

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In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses

5 June 2018

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Prolonged susceptibility to antibody-mediated neutralization for adeno-associated vectors targeted to the liver

5 June 2018

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Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver.

5 June 2018

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Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial

5 June 2018

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Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates

5 June 2018

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Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

5 June 2018

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Drinking a lot is good for dendritic cells

5 June 2018

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5 June 2018

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Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver

5 June 2018

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5 June 2018

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5 June 2018

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Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

17 August 2018

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17 August 2018

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Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus

17 August 2018

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High-throughput screening and biophysical interrogation of hepatotropic AAV.

17 August 2018

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CD8(+) T-cell responses to adeno-associated virus capsid in humans

17 August 2018

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Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice

17 August 2018

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Utility of PEGylated recombinant adeno-associated viruses for gene transfer.

17 August 2018

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Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo

17 August 2018

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10.1126/SCITRANSLMED.3005795

17 August 2018

Identifiers

DOI

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5 March 2020

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5 March 2020

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