Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate (Q42066833)

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scientific article published on March 1993

Language	Label	Description	Also known as
English	Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate	scientific article published on March 1993

Statements

scholarly article

1 reference

Europe PubMed Central

16 October 2017

Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate (English)

1 reference

Europe PubMed Central

16 October 2017

author name string

A M Casillas

1

1 reference

Europe PubMed Central

16 October 2017

K Amaral

2

1 reference

Europe PubMed Central

16 October 2017

S Chegini-Farahani

3

1 reference

Europe PubMed Central

16 October 2017

A E Nel

4

1 reference

Europe PubMed Central

16 October 2017

language of work or name

0 references

publication date

1 March 1993

1 reference

Europe PubMed Central

16 October 2017

Biochemical Journal

1 reference

Europe PubMed Central

16 October 2017

290 ( Pt 2)

1 reference

Europe PubMed Central

16 October 2017

545-550

1 reference

Europe PubMed Central

16 October 2017

Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter

1 reference

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5 June 2018

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1 reference

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Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

1 reference

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5 June 2018

Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells

1 reference

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5 June 2018

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

The structure and regulation of protein phosphatases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

Okadaic acid activates microtubule-associated protein kinase in quiescent fibroblastic cells

1 reference

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An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control

1 reference

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Okadaic acid stimulates the activity of microtubule associated protein kinase in PC-12 pheochromocytoma cells

1 reference

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5 June 2018

Okadaic acid: a new probe for the study of cellular regulation

1 reference

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5 June 2018

Stimulation of MAP-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2.

1 reference

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5 June 2018

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1 reference

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5 June 2018

Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

Inhibition of protein phosphatases by okadaic acid induces AP1 in human T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

Protein kinase C plays a role in the induction of tyrosine phosphorylation of lymphoid microtubule-associated protein-2 kinase. Evidence for a CD3-associated cascade that includes pp56lck and that is defective in HPB-ALL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

Phosphatases PP1 and PP2A act after the G0/G1 interface in lymphocyte activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

Stimulation of B-cells via the membrane immunoglobulin receptor or with phorbol myristate 13-acetate induces tyrosine phosphorylation and activation of a 42-kDa microtubule-associated protein-2 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

Tyrosyl Phosphorylation and Activation of MAP Kinases by p56lck

1 reference

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5 June 2018

MAP kinase by any other name smells just as sweet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132308

5 June 2018

Phorbol ester induces tyrosine phosphorylation in normal and abnormal human B lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8452545

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8452545

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD-3-mediated activation of MAP-2 kinase can be modified by ligation of the CD4 receptor. Evidence for tyrosine phosphorylation during activation of this kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8452545

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/8452545

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8452545

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/8452545

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ2900545

1 reference

Europe PubMed Central

16 October 2017

1 reference

Europe PubMed Central

16 October 2017

1 reference

Europe PubMed Central

16 October 2017

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