Klotho is a substrate for alpha-, beta- and gamma-secretase (Q42078322)

16 October 2017

Klotho is a substrate for alpha-, beta- and gamma-secretase (English)

1 reference

16 October 2017

Laura Bloch

1

1 reference

16 October 2017

Olga Sineshchekova

2

1 reference

16 October 2017

Daniela Reichenbach

3

1 reference

16 October 2017

Karina Reiss

4

1 reference

16 October 2017

Paul Saftig

5

1 reference

16 October 2017

Makoto Kuro-o

6

1 reference

16 October 2017

Christoph Kaether

7

1 reference

16 October 2017

language of work or name

English

0 references

publication date

6 September 2009

1 reference

16 October 2017

1 reference

16 October 2017

583

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16 October 2017

19

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16 October 2017

3221-3224

1 reference

Cell biology, regulation and inhibition of beta-secretase (BACE-1).

16 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Klotho as a regulator of oxidative stress and senescence

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Augmented Wnt signaling in a mammalian model of accelerated aging

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Klotho converts canonical FGF receptor into a specific receptor for FGF23

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Regulation of fibroblast growth factor-23 signaling by klotho

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Regulation of oxidative stress by the anti-aging hormone klotho

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Suppression of aging in mice by the hormone Klotho

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Gamma-secretase: proteasome of the membrane?

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2757472

Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19737556

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19737556

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.FEBSLET.2009.09.009

1 reference

16 October 2017

1 reference

16 October 2017

1 reference