Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon (Q42084058)

16 October 2017

Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon (English)

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16 October 2017

1

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16 October 2017

Daniel L Alkon

2

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16 October 2017

Thomas J Nelson

series ordinal

3

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16 October 2017

language of work or name

English

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publication date

17 March 2012

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16 October 2017

12

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Journal of Biological Chemistry

inferred from page(s)

published in

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16 October 2017

287

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16 October 2017

19

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16 October 2017

15947-15958

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describes a project that uses

16 October 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3346146/fullTextXML

inferred from PubMed Central ID database lookup

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Borna disease virus blocks potentiation of presynaptic activity through inhibition of protein kinase C signaling.

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A specific amyloid-beta protein assembly in the brain impairs memory

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The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site

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Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target

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Identification of conserved amino acids N-terminal of the PKC epsilon C1b domain crucial for protein kinase C epsilon-mediated induction of neurite outgrowth.

30 May 2018

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30 May 2018

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Amyloid beta peptide directly inhibits PKC activation

30 May 2018

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Apolipoprotein E and β‐amyloid (1–42) regulation of glycogen synthase kinase‐3β

30 May 2018

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30 May 2018

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30 May 2018

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Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology

30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

30 May 2018

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

30 May 2018

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Regulation of amyloid precursor protein release by protein kinase C in Swiss 3T3 fibroblasts

30 May 2018

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Isoform-specific binding of apolipoprotein E to beta-amyloid

30 May 2018

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Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not -delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts

30 May 2018

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High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.

30 May 2018

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PKC ε activation prevents synaptic loss, Aβ elevation, and cognitive deficits in Alzheimer's disease transgenic mice

17 August 2018

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DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition.

17 August 2018

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Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks

17 August 2018

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Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

17 August 2018

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Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes

17 August 2018

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Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients

17 August 2018

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CNS synaptogenesis promoted by glia-derived cholesterol

17 August 2018

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Protein kinase C epsilon suppresses Abeta production and promotes activation of alpha-secretase.

17 August 2018

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Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

17 August 2018

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17 August 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111.312710

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

21 January 2018

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12 December 2020

Decreased levels of protein kinase C in Alzheimer brain

1 reference

12 December 2020

α, β-DCP-LA selectively activates PKC-ε and stimulates neurotransmitter release with the highest potency among 4 diastereomers

1 reference

12 December 2020

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein

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12 December 2020

Identifiers

DOI

10.1074/JBC.M111.312710

1 reference

16 October 2017

1 reference

16 October 2017

PubMed publication ID

22427674

1 reference