Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats. (Q42085364)

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scientific article published on 8 July 2009

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English	Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats.	scientific article published on 8 July 2009

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Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats (English)

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cardiovascular abnormality

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Prabhakara R Nagareddy

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Hesham Soliman

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Guorong Lin

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Padmesh S Rajput

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Ujendra Kumar

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John H McNeill

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Kathleen M MacLeod

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8 July 2009

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2355-2364

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27 August 2021

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Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats

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30 May 2018

N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats

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30 May 2018

Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy

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Role of the PKC/CPI-17 pathway in enhanced contractile responses of mesenteric arteries from diabetic rats to alpha-adrenoceptor stimulation

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Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies

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Reactive oxygen species mediate Endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells

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Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes

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Evidence for inducible nitric-oxide synthase expression and activity in vascular smooth muscle of streptozotocin-diabetic rats

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PKC-beta inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats

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Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells

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Antisense oligonucleotides targeting protein kinase C-alpha, -beta I, or -delta but not -eta inhibit lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages: involvement of a nuclear factor kappa B-dependent mechanism.

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Protein kinase C eta mediates lipopolysaccharide-induced nitric-oxide synthase expression in primary astrocytes

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Protein kinase C activation and the development of diabetic complications

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30 May 2018

The extended protein kinase C superfamily

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Activation of protein kinase C by tyrosine phosphorylation in response to H2O2.

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30 May 2018

Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy

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Pathogenetic mechanisms of septic shock

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

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30 May 2018

Alteration of 1,2-diacylglycerol content in myocardium from diabetic rats

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30 May 2018

Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications

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Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation

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30 May 2018

Chronic inhibition of inducible nitric oxide synthase ameliorates cardiovascular abnormalities in streptozotocin diabetic rats

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17 August 2018

Regulation of muscle creatine kinase by phosphorylation in normal and diabetic hearts

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17 August 2018

Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats

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17 August 2018

Acute inhibition of Rho-kinase improves cardiac contractile function in streptozotocin-diabetic rats.

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17 August 2018

The effect of ruboxistaurin on nephropathy in type 2 diabetes

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17 August 2018

Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes.

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Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase

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Temporal control of NF-kappaB activation by ERK differentially regulates interleukin-1beta-induced gene expression.

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17 August 2018

Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons

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Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes

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Effects of the superoxide dismutase-mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats

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Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress

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Telmisartan Shows an Equivalent Effect of Vitamin C in Further Improving Endothelial Dysfunction After Glycemia Normalization in Type 1 Diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587355

12 December 2020

based on heuristic

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Persistent activation of nuclear factor-kappaB by interleukin-1beta and subsequent inducible NO synthase expression requires extracellular signal-regulated kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of LY333531, a selective protein kinase C beta inhibitor, in the Fischer 344 rat and beagle dog

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phorbol esters induce nitric oxide synthase and increase arginine influx in cultured peritoneal macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-induced down-regulation of NO production and inducible NOS expression in cultured rat aortic vascular smooth muscle cells: role of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic vascular dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetylcysteine prevents nitrosative stress-associated depression of blood pressure and heart rate in streptozotocin diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High glucose enhances inducible nitric oxide synthase expression. Role of protein kinase C-βII

1 reference

https://pubmed.ncbi.nlm.nih.gov/19587355

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB09-0432

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2 February 2020

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2 February 2020

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2 February 2020

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