Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization (Q42092237)

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scientific article published on 10 March 2009

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English	Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization	scientific article published on 10 March 2009

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23 January 2020

Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization (English)

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23 January 2020

desensitization

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based on heuristic

inferred from title

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23 January 2020

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Roujian Lu

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23 January 2020

Yong Li

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Youwen Zhang

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Yunjia Chen

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Angela D Shields

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Danny G Winder

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Timothy Angelotti

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Lee E Limbird

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Yi Zhou

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Qin Wang

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23 January 2020

Journal of Biological Chemistry

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23 January 2020

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13233-13243

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23 January 2020

Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

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beta-arrestin-biased agonism at the beta2-adrenergic receptor

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Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons

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Alpha 2-adrenergic agonist enrichment of spinophilin at the cell surface involves beta gamma subunits of Gi proteins and is preferentially induced by the alpha 2A-subtype.

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Receptor endocytosis counteracts the development of opioid tolerance

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Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors

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Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy

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Agonist-dependent trafficking of alpha2-adrenoceptor subtypes: dependence on receptor subtype and employed agonist

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Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists

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Mechanisms of ligand-induced desensitization of the 5-hydroxytryptamine(2A) receptor

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Molecular components of tolerance to opiates in single hippocampal neurons

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Differential in vivo internalization of MOR-1 and MOR-1C by morphine

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Signaling on the endocytic pathway

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G protein-coupled receptor kinase mediates desensitization of norepinephrine-induced Ca2+ channel inhibition

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Gene Substitution/Knockout to Delineate the Role of alpha2-Adrenoceptor Subtypes in Mediating Central Effects of Catecholamines and Imidazolines

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19276088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bioavailability and pharmacokinetics of guanfacine after oral and intravenous administration to healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19276088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LHRH and GTP-gamma-S modify calcium current activation in bullfrog sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19276088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M807535200

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19276088%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19276088%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19276088%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

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