Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. (Q42101410)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26838599%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

title

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD (English)

1 reference

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7 March 2020

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22

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7 March 2020

Alexandra Montagner

1

1 reference

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7 March 2020

Simon Ducheix

4

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7 March 2020

Yannick Lippi

5

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7 March 2020

Fabienne Rajas

17

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7 March 2020

Sandrine Lagarrigue

18

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7 March 2020

Nicolas Loiseau

20

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7 March 2020

Catherine Postic

21

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7 March 2020

Hervé Guillou

24

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7 March 2020

author name string

Arnaud Polizzi

2

1 reference

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7 March 2020

Edwin Fouché

3

1 reference

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7 March 2020

Frédéric Lasserre

6

1 reference

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7 March 2020

Valentin Barquissau

7

1 reference

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7 March 2020

Marion Régnier

8

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7 March 2020

Céline Lukowicz

9

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7 March 2020

Fadila Benhamed

10

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7 March 2020

Alison Iroz

11

1 reference

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7 March 2020

Justine Bertrand-Michel

12

1 reference

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7 March 2020

Talal Al Saati

13

1 reference

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7 March 2020

Patricia Cano

14

1 reference

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7 March 2020

Laila Mselli-Lakhal

15

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7 March 2020

Gilles Mithieux

16

1 reference

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7 March 2020

Thierry Pineau

19

1 reference

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7 March 2020

Walter Wahli

23

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7 March 2020

language of work or name

English

0 references

publication date

1 February 2016

1 reference

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7 March 2020

1 reference

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7 March 2020

volume

65

1 reference

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7 March 2020

page(s)

1202-1214

1 reference

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7 March 2020

issue

7

1 reference

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Fatty acids from fat cell lipolysis do not activate an inflammatory response but are stored as triacylglycerols in adipose tissue macrophages

7 March 2020

cites work

1 reference

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Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

29 May 2018

1 reference

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Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids

29 May 2018

1 reference

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PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

29 May 2018

1 reference

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Activation of aryl hydrocarbon receptor dissociates fatty liver from insulin resistance by inducing fibroblast growth factor 21.

29 May 2018

1 reference

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Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

29 May 2018

1 reference

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Nutrient-sensing nuclear receptors coordinate autophagy

29 May 2018

1 reference

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Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

29 May 2018

1 reference

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Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet

29 May 2018

1 reference

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Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets

29 May 2018

1 reference

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Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.

29 May 2018

1 reference

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Integrated physiology and systems biology of PPARα

29 May 2018

1 reference

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Inventing new medicines: The FGF21 story

29 May 2018

1 reference

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Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH)

29 May 2018

1 reference

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New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease

29 May 2018

1 reference

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Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21.

29 May 2018

1 reference

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Altered lipid metabolism in residual white adipose tissues of Bscl2 deficient mice

29 May 2018

1 reference

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A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.

29 May 2018

1 reference

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From NAFLD to NASH to cirrhosis-new insights into disease mechanisms.

29 May 2018

1 reference

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Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

29 May 2018

1 reference

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PPARs at the crossroads of lipid signaling and inflammation

29 May 2018

1 reference

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Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation.

29 May 2018

1 reference

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Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

29 May 2018

1 reference

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Identification of a physiologically relevant endogenous ligand for PPARalpha in liver

29 May 2018

1 reference

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Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

29 May 2018

1 reference

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Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

29 May 2018

1 reference

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

29 May 2018

1 reference

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Bioconductor: open software development for computational biology and bioinformatics

29 May 2018

1 reference

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Molecular mediators of hepatic steatosis and liver injury

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

PPARalpha governs glycerol metabolism

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

The global NAFLD epidemic

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Role of peroxisome proliferator-activated receptor-alpha in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 protein expression in starvation and after refeeding

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941147

Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1136%2FGUTJNL-2015-310798

Genome-wide analysis of PPARα activation in murine small intestine

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26838599

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1136/GUTJNL-2015-310798

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26838599%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26838599%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26838599%20AND%20SRC:MED&resulttype=core&format=json