Significant impact of promoter hypermethylation and the 540 C>T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase (Q42104167)

16 October 2017

Significant impact of promoter hypermethylation and the 540 C>T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase (English)

1 reference

16 October 2017

1 reference

4

Kari Hemminki

1 reference

16 October 2017

5

Lars Andreas Akslen

1 reference

16 October 2017

2

Johanna Smeds

1 reference

16 October 2017

1

Oddbjørn Straume

1 reference

16 October 2017

Rajiv Kumar

3

1 reference

PMCID

1850679

16 October 2017

language of work or name

English

0 references

publication date

1 July 2002

1 reference

The American Journal of Pathology

16 October 2017

1 reference

16 October 2017

161

1 reference

16 October 2017

229-237

1 reference

16 October 2017

1

1 reference

p16(MTS-1/CDKN2/INK4a) in cancer progression

16 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Aberrant promoter methylation of multiple genes in non-small cell lung cancers.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

The 3' untranslated region of messenger RNA: A molecular 'hotspot' for pathology?

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

The genetics of hereditary melanoma and nevi. 1998 update

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Hypermethylation of tumor suppressor genes in cancer

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanoma

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Inactivation of p16 in human mammary epithelial cells by CpG island methylation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Role of the p16 tumor suppressor gene in cancer

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

A cell cycle regulator potentially involved in genesis of many tumor types

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Germline p16 mutations in familial melanoma

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

A novel p16INK4A transcript

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

The histogenesis and biologic behavior of primary human malignant melanomas of the skin

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Promoter hypermethylation: a common cause of reduced p16(INK4a) expression in uveal melanoma.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

The p16INK4a/CDKN2A tumor suppressor and its relatives.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Disruption of the RB pathway and cell-proliferative activity in non-small-cell lung cancers.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Correlation of Ki-67 antigen expression with mitotic figure index and tumor grade in breast carcinomas using the novel "paraffin"-reactive MIB1 antibody.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

K-ras and p16 aberrations confer poor prognosis in human colorectal cancer

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Hypermethylation of the p16 Gene in Sporadic T3N0M0 Stage Colorectal Cancers: Association with DNA Replication Error and Shorter Survival

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850679

Genetic basis of susceptibility to melanoma

1 December 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

Mutations in the CDKN2A ( p16INK4a ) gene in microdissected sporadic primary melanomas

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

7 January 2021

inferred from DOI database lookup

p16INK4a inactivation is not frequent in uncultured sporadic primary cutaneous melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

Analysis of the tumor suppressor gene p16(INK4A) in microdissected melanoma metastases by sequencing, and microsatellite and methylation screening

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

Loss of heterozygosity in sporadic primary cutaneous melanoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

Loss of heterozygosity at chromosome 9p21 (INK4-p14ARF locus): homozygous deletions and mutations in the p16 and p14ARF genes in sporadic primary melanomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

A single nucleotide polymorphism in the 3?untranslated region of theCDKN2A gene is common in sporadic primary melanomas but mutations in theCDKN2B,CDKN2C,CDK4 andp53 genes are rare

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

7 January 2021

12 December 2020

Reduced survival in patients with ductal pancreatic adenocarcinoma associated with CDKN2 mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

p16 inactivation in small-sized lung adenocarcinoma: its association with poor prognosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

Lack of mutation at p16INK4A gene but expression of aberrant p16INK4A RNA transcripts in human ovarian carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

Aberrant p27Kip1 promoter methylation in malignant melanoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

Infrequent Mutation of p16INK4 in Sporadic Melanoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

p16/CDKN2 andCDK4 gene mutations in sporadic melanoma development and progression

7 January 2021

2 references

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

7 January 2021

12 December 2020

Analysis of G1/S checkpoint regulators in metastatic melanoma

2 references

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964174-0

7 January 2021

12 December 2020

Loss of p16 protein expression associated with methylation of the p16INK4A gene is a frequent finding in Hodgkin's disease

1 reference

12 December 2020

Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma

1 reference

12 December 2020

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing

1 reference

12 December 2020

High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma

1 reference

12 December 2020

Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies

1 reference

12 December 2020

Altered p16/MTS1/CDKN2 and cyclin D1/PRAD-1 gene expression is associated with the prognosis of squamous cell carcinoma of the esophagus

1 reference

12 December 2020

10.1016/S0002-9440(10)64174-0

Identifiers

DOI

1 reference

16 October 2017

1 reference

16 October 2017

1 reference

PMCID

1850679