JTT-501, a novel oral antidiabetic agent, improves insulin resistance in genetic and non-genetic insulin-resistant models (Q42106486)

16 October 2017

JTT-501, a novel oral antidiabetic agent, improves insulin resistance in genetic and non-genetic insulin-resistant models (English)

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16 October 2017

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Shibata T

1

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16 October 2017

Matsui K

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2

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16 October 2017

Yonemori F

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3

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16 October 2017

Wakitani K

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4

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16 October 2017

language of work or name

English

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publication date

1 December 1998

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British Journal of Pharmacology

16 October 2017

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16 October 2017

125

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16 October 2017

8

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16 October 2017

1744-1750

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Leptin: the tale of an obesity gene

16 October 2017

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Characterization of new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and Zucker fatty rats

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Treatment with CL 316,243, a beta 3-adrenoceptor agonist, reduces serum leptin in rats with diet- or aging-associated obesity, but not in Zucker rats with genetic (fa/fa) obesity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Insulin receptor tyrosine-kinase activity is altered in both muscle and adipose tissue from non-obese normoglycaemic insulin-resistant subjects

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Increased obese mRNA expression in omental fat cells from massively obese humans

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Effect of pioglitazone on insulin receptors of skeletal muscles from high-fat-fed rats

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Troglitazone prevents glucose-induced insulin resistance of insulin receptor in rat-1 fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Pioglitazone Increases Insulin Sensitivity by Activating Insulin Receptor Kinase

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in nonobese subjects with NIDDM.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Pioglitazone ameliorates high glucose induced desensitization of insulin receptor kinase in Rat 1 fibroblasts in culture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

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7 January 2021

Leptin receptor missense mutation in the fatty Zucker rat.

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Banting lecture 1988. Role of insulin resistance in human disease

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Thiazolidinediones in the treatment of insulin resistance and type II diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds as hypoglycemic agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Actions of novel antidiabetic agent englitazone in hyperglycemic hyperinsulinemic ob/ob mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

The antihyperglycemic agent englitazone prevents the defect in glucose transport in rats fed a high-fat diet

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Molecular cloning of rat leptin receptor isoform complementary DNAs--identification of a missense mutation in Zucker fatty (fa/fa) rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Aetiology of non-insulin dependent diabetes

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Role of JTT-501, a new insulin sensitiser, in restoring impaired GLUT4 translocation in adipocytes of rats fed a high fat diet.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Positional cloning of the mouse obese gene and its human homologue

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https://api.crossref.org/works/10.1038%2FSJ.BJP.0702253

7 January 2021

Identifiers

DOI

10.1038/SJ.BJP.0702253

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16 October 2017

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16 October 2017

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