Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells (Q42108183)

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scientific article published on November 1998

Language	Label	Description	Also known as
English	Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells	scientific article published on November 1998

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scholarly article

1 reference

Europe PubMed Central

16 October 2017

Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells (English)

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Europe PubMed Central

16 October 2017

2

1 reference

Europe PubMed Central

16 October 2017

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Europe PubMed Central

16 October 2017

author name string

Klein U

1

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Europe PubMed Central

16 October 2017

language of work or name

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publication date

1 November 1998

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Europe PubMed Central

16 October 2017

Journal of Experimental Medicine

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Europe PubMed Central

16 October 2017

188

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Europe PubMed Central

16 October 2017

1679-1689

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Europe PubMed Central

16 October 2017

9

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Europe PubMed Central

16 October 2017

The normal counterpart of IgD myeloma cells in germinal center displays extensively mutated IgVH gene, Cmu-Cdelta switch, and lambda light chain expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Memory B cells are biased towards terminal differentiation: a strategy that may prevent repertoire freezing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Lack of allelic exclusion in B cell chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Germinal center founder cells display propensity for apoptosis before onset of somatic mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Memory B lymphocytes migrate to bone marrow in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

B-1 cells: unique origins and functions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enh

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Clonal selection and learning in the antibody system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Analysis of somatic mutation in five B cell subsets of human tonsil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Secondary deletional recombination of rearranged switch region in Ig isotype-switched B cells. A mechanism for isotype stabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

CD27-CD70 interactions regulate B-cell activation by T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Memory B cells at successive stages of differentiation. Affinity maturation and the role of IgD receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

The relationship between surface immunoglobulin isotype and the immune function of murine B lymphocytes. V. High affinity secondary antibody responses are transferred by both IgD-positive and IgD-negative memory B cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Determination of antibody class in a system of cooperating antigenic determinants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Directed Ig class switch recombination in activated murine B cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

CD27 expression by a distinct subpopulation of human B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Cells in the marginal zone of the spleen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Natural occurrence and origin of somatically mutated memory B cells in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

29 May 2018

Somatic hypermutation in normal and transformed human B cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

17 August 2018

Generation of plasma cells from peripheral blood memory B cells: synergistic effect of interleukin-10 and CD27/CD70 interaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

17 August 2018

Memory, but not naive, peripheral blood B lymphocytes differentiate into Ig-secreting cells after CD40 ligation and costimulation with IL-4 and the differentiation factors IL-2, IL-10, and IL-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

17 August 2018

Evidence for a large compartment of IgM-expressing memory B cells in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

17 August 2018

Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

17 August 2018

Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

17 August 2018

Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

17 August 2018

Memory B lymphocytes in human tonsil do not express surface IgD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

17 August 2018

Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

17 August 2018

High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212515

17 August 2018

Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotype and function of human B cells expressing CD70 (CD27 ligand)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

V(D)J recombinase activity in a subset of germinal center B lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magnetofluorescent liposomes for increased sensitivity of immunofluorescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pairing of variable heavy and variable kappa chains in individual naive and memory B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The frequency of multiple recombination events occurring at the human Ig kappa L chain locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IgM and IgG but not cytokine secretion is restricted to the CD27+ B lymphocyte subset

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process

1 reference

https://pubmed.ncbi.nlm.nih.gov/9802980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.188.9.1679

1 reference

Europe PubMed Central

16 October 2017

1 reference

Europe PubMed Central

16 October 2017

1 reference

Europe PubMed Central

16 October 2017

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