A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats. (Q42108571)

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scientific article published on March 2006

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English	A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats.	scientific article published on March 2006

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scholarly article

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15 January 2020

A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats (English)

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15 January 2020

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allergic asthma

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based on heuristic

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2

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15 January 2020

Esteban Morcillo

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15 January 2020

Yafa Naim Abu Nabah

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Yafa Naim Abu Nabah

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15 January 2020

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Julio Cortijo

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15 January 2020

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Arantxa Iranzo

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15 January 2020

José Luis Montesinos

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15 January 2020

José Alfón

6

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15 January 2020

Luis A Gómez

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1 March 2006

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15 January 2020

British Journal of Pharmacology

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15 January 2020

147

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15 January 2020

6

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15 January 2020

661-670

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15 January 2020

The role of eosinophils in the pathogenesis of asthma

1 reference

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29 May 2018

The identification and optimization of orally efficacious, small molecule VLA-4 antagonists

1 reference

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29 May 2018

Reassessing the Th2 cytokine basis of asthma

1 reference

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29 May 2018

Development of cell adhesion molecule antagonists as therapeutics for asthma and COPD.

1 reference

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29 May 2018

The effect of anti-integrin monoclonal antibodies on antigen-induced pulmonary inflammation in allergic rabbits.

1 reference

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In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats

1 reference

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29 May 2018

Functional characterization and biomarker identification in the Brown Norway model of allergic airway inflammation

1 reference

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29 May 2018

Rolipram inhibits leukocyte-endothelial cell interactions in vivo through P- and E-selectin downregulation

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29 May 2018

A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat.

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29 May 2018

Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge

1 reference

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29 May 2018

Effect of alpha4-integrin blockade on CD4+ cell-driven late airway responses in the rat.

1 reference

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29 May 2018

Molecular basis for selective eosinophil trafficking in asthma: A multistep paradigm.

1 reference

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29 May 2018

Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751336

29 May 2018

IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions

1 reference

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29 May 2018

VCAM-1/alpha 4-integrin adhesion pathway: therapeutic target for allergic inflammatory disorders

1 reference

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29 May 2018

The role of alpha 4 integrins in lung pathophysiology.

1 reference

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29 May 2018

Interleukin 4 or oncostatin M induces a prolonged increase in P-selectin mRNA and protein in human endothelial cells

1 reference

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29 May 2018

Mechanisms of increased airway microvascular permeability: role in airway inflammation and obstruction

1 reference

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29 May 2018

Leukotrienes in bile during the early and the late airway responses after allergen challenge of sensitized rats.

1 reference

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29 May 2018

Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep

1 reference

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29 May 2018

Antibody to very late activation antigen 4 prevents antigen-induced bronchial hyperreactivity and cellular infiltration in the guinea pig airways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751336

29 May 2018

Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751336

29 May 2018

In situ expression of the cell adhesion molecules in bronchial tissues from asthmatics with air flow limitation: in vivo evidence of VCAM-1/VLA-4 interaction in selective eosinophil infiltration

1 reference

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29 May 2018

Leukocyte-endothelial adhesion molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751336

29 May 2018

Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes

1 reference

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29 May 2018

Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors

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29 May 2018

Inflammatory mediators and cellular infiltration of the lungs in a guinea pig model of the late asthmatic reaction.

1 reference

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29 May 2018

Airway hyperresponsiveness is associated with inflammatory cell infiltration in allergic brown-Norway rats.

1 reference

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29 May 2018

Intercellular adhesion molecule-1 (ICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in the bronchial mucosa of normal and asthmatic subjects

1 reference

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29 May 2018

The influence of antigen dose on IgE production in different rat strains

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29 May 2018

Leukocyte-endothelium adhesion: microhemodynamics in mesentery of the cat.

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29 May 2018

Erythromycin exerts in vivo anti-inflammatory activity downregulating cell adhesion molecule expression.

1 reference

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17 August 2018

Effects of bemiparin on airway responses to antigen in sensitized Brown-Norway rats

1 reference

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17 August 2018

Oral N-acetylcysteine attenuates the rat pulmonary inflammatory response to antigen.

1 reference

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17 August 2018

A small molecule very late antigen-4 antagonist can inhibit ovalbumin-induced lung inflammation

1 reference

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17 August 2018

Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow

1 reference

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17 August 2018

Pulmonary eosinophilia in a murine model of allergic inflammation is attenuated by small molecule alpha4beta1 antagonists

1 reference

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17 August 2018

Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist

1 reference

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17 August 2018

VCAM-1 is more effective than MAdCAM-1 in supporting eosinophil rolling under conditions of shear flow.

1 reference

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17 August 2018

IL-4-induced eosinophil accumulation in rat skin is dependent on endogenous TNF-alpha and alpha 4 integrin/VCAM-1 adhesion pathways.

1 reference

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17 August 2018

Antibody to very late activation antigen 4 prevents interleukin-5-induced airway hyperresponsiveness and eosinophil infiltration in the airways of guinea pigs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751336

17 August 2018

The role of the leukocyte adhesion molecules VLA-4, LFA-1, and Mac-1 in allergic airway responses in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751336

17 August 2018

Regulation of alpha 4 integrin-mediated adhesion of human eosinophils to fibronectin and vascular cell adhesion molecule-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of adhesion molecules ICAM-1 and alpha4 integrin in antigen-induced changes in microvascular permeability associated with lung inflammation in sensitized brown Norway rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat neutrophils express alpha4 and beta1 integrins and bind to vascular cell adhesion molecule-1 (VCAM-1) and mucosal addressin cell adhesion molecule-1 (MAdCAM-1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of alpha4 (CD49d) and beta2 (CD18) integrins in eosinophil and neutrophil migration to allergic lung inflammation in the Brown Norway rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: a critical role for the alpha 4 integrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engagement of alpha4beta7 integrins by monoclonal antibodies or ligands enhances survival of human eosinophils in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of inhaled glaucine on pulmonary responses to antigen in sensitized guinea pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small-molecule, tight-binding inhibitor of the integrin alpha(4)beta(1) blocks antigen-induced airway responses and inflammation in experimental asthma in sheep

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of CD49d inhibits allergic airway pathologies independent of effects on leukocyte recruitment

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrinsic AHR in IL-5 transgenic mice is dependent on CD4(+) cells and CD49d-mediated signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic factors in non-specific bronchial reactivity in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoglobulin E-mediated increase in vascular permeability correlates with eosinophilic inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of endothelial and leukocyte adhesion molecules intercellular adhesion molecule-1, E-selectin, and vascular cell adhesion molecule-1 in the bronchial mucosa in steady-state and allergen-induced asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the VLA-4 integrin in leucocyte recruitment and bronchial hyperresponsiveness in the guinea-pig

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of very late activation antigen-4 in the antigen-induced accumulation of eosinophils and lymphocytes in the lungs and airway lumen of sensitized brown Norway rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin alpha4beta7 mediates human eosinophil interaction with MAdCAM-1, VCAM-1 and fibronectin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of late-phase airway responses and airway hyperresponsiveness in allergic sheep with a small-molecule peptide inhibitor of VLA-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432509

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/SJ.BJP.0706658

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16432509%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

release_ig32kp64rffgvknf67yic6fnkm

1 reference

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24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16432509%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16432509%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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