Different distribution of morphine and morphine-6 beta-glucuronide after intracerebroventricular injection in rats (Q42113228)

16 October 2017

Different distribution of morphine and morphine-6 beta-glucuronide after intracerebroventricular injection in rats (English)

1 reference

16 October 2017

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Takashi Okura

1

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16 October 2017

Masanori Saito

2

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16 October 2017

Misato Nakanishi

3

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16 October 2017

Noriyuki Komiyama

4

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16 October 2017

Aki Fujii

5

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16 October 2017

Shizuo Yamada

6

1 reference

16 October 2017

Ryohei Kimura

7

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16 October 2017

language of work or name

English

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publication date

4 August 2003

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British Journal of Pharmacology

16 October 2017

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16 October 2017

140

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16 October 2017

1

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16 October 2017

211-217

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Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine

16 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats--pharmacokinetic/pharmacodynamic modelling

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Morphine-6 beta-glucuronide has a higher efficacy than morphine as a mu-opioid receptor agonist in the rat locus coeruleus

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Prediction of in vivo tissue distribution from in vitro data 1. Experiments with markers of aqueous spaces

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Antinociceptive effects of morphine-6-glucuronide in homozygous MDR1a P-glycoprotein knockout and in wildtype mice in the hotplate test

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

The spinal loop dialysis catheter: characterization of use in the unanesthetized rat.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Mapping of opioid receptors using antisense oligodeoxynucleotides: correlating their molecular biology and pharmacology

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Morphine-6-glucuronide: analgesic effects and receptor binding profile in rats

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Morphine 6-glucuronide and morphine 3-glucuronide as molecular chameleons with unexpected lipophilicity

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Elevated concentrations of morphine 6-beta-D-glucuronide in brain extracellular fluid despite low blood-brain barrier permeability

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Blood-brain barrier permeability to morphine-6-glucuronide is markedly reduced compared with morphine

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Kinetics of drug metabolism in rat liver slices. III. Relationship between metabolic clearance and slice uptake rate.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Kinetics of active efflux via choroid plexus of beta-lactam antibiotics from the CSF into the circulation

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574014

The disposition of morphine and its metabolites in the in-situ rat isolated perfused liver

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJP.0705418

Nasal absorption of zidovudine and its transport to cerebrospinal fluid in rats

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJP.0705418

Metabolism of Drugs. LX. The Synthesis of Codeine and Morphine Glucuronides

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJP.0705418

Distribution of morphine 6-glucuronide and morphine across the blood-brain barrier in awake, freely moving rats investigated by in vivo microdialysis sampling

21 January 2018

1 reference

12 December 2020

Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat

1 reference

12 December 2020

Cerebrospinal fluid distribution of opioids after intraventricular & lumbar subarachnoid administration in sheep

1 reference

12 December 2020

Intestinal absorption and stability of morphine 6-glucuronide in different physiological compartments of the rat

1 reference

12 December 2020

In-vivo and in-vitro evidence of a carrier-mediated efflux transport system for oestrone-3-sulphate across the blood-cerebrospinal fluid barrier

1 reference

12 December 2020

Multiplicative interaction between narcotic agonisms expressed at spinal and supraspinal sites of antinociceptive action as revealed by concurrent intrathecal and intracerebroventricular injections of morphine

1 reference

12 December 2020

Effect of heparin or salicylate infusion on serum protein binding and on concentrations of phenytoin in serum, brain and cerebrospinal fluid of rats

1 reference

12 December 2020

Fast reliable assay for morphine and its metabolites using high-performance liquid chromatography and native fluorescence detection

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0705418

1 reference

release_mv7g6pbbkvh4njbgoqlc4ur25m

16 October 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mv7g6pbbkvh4njbgoqlc4ur25m

24 November 2022

mapped directly with Wikidata item

1 reference

16 October 2017

PubMed publication ID

12967951

1 reference