Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis (Q42135414)

17 October 2017

Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis (English)

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17 October 2017

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Koji Takayama

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17 October 2017

Yohei Kawakami

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17 October 2017

Makoto Kobayashi

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17 October 2017

Nick Greco

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17 October 2017

James H Cummins

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17 October 2017

Takehiko Matsushita

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17 October 2017

Ryosuke Kuroda

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17 October 2017

Masahiro Kurosaka

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17 October 2017

Freddie H Fu

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17 October 2017

Johnny Huard

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17 October 2017

17 November 2014

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Arthritis Research and Therapy

17 October 2017

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17 October 2017

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17 October 2017

482

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Creative Commons Attribution 4.0 International

17 October 2017

start time

17 November 2014

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Osteoarthritis year 2011 in review: biology

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Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

29 May 2018

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Autophagy activation by rapamycin reduces severity of experimental osteoarthritis.

29 May 2018

1 reference

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Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection.

29 May 2018

1 reference

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The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse.

29 May 2018

1 reference

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Osteochondral plate angiogenesis: a new treatment target in osteoarthritis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Articular cartilage mineralization in osteoarthritis of the hip.

29 May 2018

1 reference

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Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways

29 May 2018

1 reference

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Calcification of articular cartilage in human osteoarthritis.

29 May 2018

1 reference

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Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Sirolimus to replace calcineurin inhibitors? Too early yet.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Autophagy: a lysosomal degradation pathway with a central role in health and disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Autophagy fights disease through cellular self-digestion

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Autophagy in the Pathogenesis of Disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

29 May 2018

1 reference

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Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

The TOR pathway: a target for cancer therapy

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Development by self-digestion: molecular mechanisms and biological functions of autophagy

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Developmental regulation of the growth plate

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Different bone growth rates are associated with changes in the expression pattern of types II and X collagens and collagenase 3 in proximal growth plates of the rat tibia

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Identification and characterization of up-regulated genes during chondrocyte hypertrophy

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Quantitative histological changes in osteoarthritic hip cartilage. Morphometric analysis of 29 osteoarthritic and 26 normal human femoral heads.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Remodelling of collagen types I, II and X and calcification of human fetal cartilage

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Consequences of chondrocyte hypertrophy on osteoarthritic cartilage: potential effect on angiogenesis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Rapamycin induces growth retardation by disrupting angiogenesis in the growth plate

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Rapamycin protects allografts from rejection while simultaneously attacking tumors in immunosuppressed mice

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4269094

Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

17 August 2018

1 reference

12 December 2020

In vivo kinematics comparison of fixed- and mobile-bearing total knee arthroplasty during deep knee bending motion

1 reference

12 December 2020

Rapamycin retards growth and causes marked alterations in the growth plate of young rats

1 reference

12 December 2020

The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse

1 reference

12 December 2020

10.1186/S13075-014-0482-4

Identifiers

DOI

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Dimensions Publication ID

17 October 2017

0 references

1 reference

17 October 2017

PubMed publication ID

25403236

1 reference