Mitomycins syntheses: a recent update (Q42154508)

17 October 2017

1 reference

title

Mitomycins syntheses: a recent update (English)

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17 October 2017

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ChEBI release 2020-05-28

ChEBI ID

25357

author name string

Jean-Christophe Andrez

series ordinal

1

1 reference

17 October 2017

8 July 2009

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Beilstein Journal of Organic Chemistry

17 October 2017

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17 October 2017

5

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17 October 2017

33

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Isolation of new fractions of antitumor mitomycins

17 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Synthesis of potential early-stage intermediates in the biosynthesis of FR900482 and mitomycin C.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Asymmetric catalysis mediated by synthetic peptides.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Synthetic and biosynthetic studies on FR900482 and mitomycin C: an efficient and stereoselective hydroxymethylation of an advanced benzazocane intermediate

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

A convenient allylsilane-N-acyliminium route toward indolizidine and quinolizidine alkaloids

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Internal azomethine ylide cycloaddition methodology for access to the substitution pattern of aziridinomitosene A.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Synthesis of an advanced intermediate en route to the mitomycin natural products.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Design and synthesis of a DNA-crosslinking azinomycin analogue.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Synthetic studies on heterocyclic natural products

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Transition-metal-catalyzed addition of heteroatom-hydrogen bonds to alkynes

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Synthesis of oxygen- and nitrogen-containing heterocycles by ring-closing metathesis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Mechanisms of in situ activation for DNA-targeting antitumor agents

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

DNA cross-linking by azinomycin B: Monte Carlo simulations in the evaluation of sequence selectivity

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Aziridinomitosenes by anionic cyclization: deuterium as a removable blocking group

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Mitomycin C: a clinical update

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

FK317: a novel substituted dihydrobenzoxazine with potent antitumor activity which does not induce vascular leak syndrome

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Sequence-selective alkylation and cross-linking induced by mitomycin C upon activation by DT-diaphorase

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Azicemicins A and B, a new antimicrobial agent produced by Amycolatopsis. I. Taxonomy, fermentation, isolation, characterization and biological activities.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Mitomycin antibiotics. Synthesis of 1-substituted 7-methoxymitosenes.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

A variation of the sulfide contraction procedure for synthesis of corrinoid systems.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Therapeutic attack of hypoxic cells of solid tumors: presidential address

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Maduropeptin, a complex of new macromolecular antitumor antibiotics

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Structure and stereochemistry of some 1,2-disubstituted mitosenes from solvolysis of mitomycin C and Mitomycin A

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Natural product synthesis and vitamin B12

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Mitomycin antibiotics. Synthesis and activity of 1,2-disubstituted mitosenes

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

N-silyl protecting groups for labile aziridines: application toward the synthesis of N-H aziridinomitosenes

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Mitomycin synthetic studies: stereocontrolled and convergent synthesis of a fully elaborated aziridinomitosane.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Allylic tantalums as highly imine-selective reagents.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Synthetic enantiopure aziridinomitosenes: preparation, reactivity, and DNA alkylation studies

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

MITOMYCINS AND PORFIROMYCIN: CHEMICAL MECHANISM OF ACTIVATION AND CROSS-LINKING OF DNA.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

BINAP/AgOTf/KF/18-crown-6 as new bifunctional catalysts for asymmetric Sakurai-Hosomi allylation and Mukaiyama aldol reaction

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Concise enantioselective synthesis of (+)-FR66979 and (+)-FR900482: dimethyldioxirane-mediated construction of the hydroxylamine hemiketal

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Metal-mediated synthesis of medium-sized rings.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Inhibition of DNA cross-linking by mitomycin C by peroxidase-mediated oxidation of mitomycin C hydroquinone

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Formation of 9,10-unsaturation in the mitomycins: facile fragmentation of beta-alkyl-beta-aryl-alpha-oxo-gamma-butyrolactones.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

The mitomycin antibiotics. Synthetic studies. XX. N-substituted carbamoyl and acyl esters of a related 3-hydroxymethyl-4,7-indoloquinone

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Advances in Nitrogen Transfer Reactions Involving Aziridines

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Sulfoximines as Ligands in Copper-Catalyzed Asymmetric Vinylogous Mukaiyama-Type Aldol Reactions

30 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748694

Sharpless asymmetric dihydroxylation of 5-aryl-2-vinylfurans: application to the synthesis of the spiroketal moiety of papulacandin D

1 December 2018

1 reference

12 December 2020

Catalytic Asymmetric Vinylogous Mukaiyama-aldol (CAVM) reactions: the enolate activation

1 reference

12 December 2020

Asymmetric Mukaiyama-Michael addition of acyclic enones catalyzed by allo-threonine-derived B-aryloxazaborolidinones

1 reference

12 December 2020

Mapping the mitomycin biosynthetic pathway by functional analysis of the MitM aziridine N-methyltransferase

1 reference

12 December 2020

Intramolecular 1,3-dipolar cycloaddition strategy for enantioselective synthesis of FR-900482 analogues

1 reference

12 December 2020

A Simple, Mild, Catalytic, Enantioselective Addition of Terminal Acetylenes to Aldehydes

1 reference

12 December 2020

Catalytic Enantioselective Addition to Imines

1 reference

12 December 2020

Additions of Organometallic Reagents to C=N Bonds: Reactivity and Selectivity

1 reference

12 December 2020

Role of the azinomycin naphthoate and central amide in sequence-dependent DNA alkylation and cytotoxicity of epoxide-bearing substructures

1 reference

12 December 2020

Total synthesis of (+/-)-FR66979

1 reference

12 December 2020

Carzinophilin, a new tumor inhibitory substance produced by streptomyces. I

1 reference

12 December 2020

Zn(pybox)-complex-catalyzed asymmetric aqueous Mukaiyama-aldol reactions

1 reference

12 December 2020

Hydroxyquinone O-methylation in mitomycin biosynthesis

1 reference

12 December 2020

Progress in combinatorial biosynthesis for drug discovery

1 reference

12 December 2020

DNA cross-linking by intermediates in the mitomycin activation cascade

1 reference

12 December 2020

Transition Metal Catalyzed Synthesis of Arylamines and Aryl Ethers from Aryl Halides and Triflates: Scope and Mechanism

1 reference

12 December 2020

Reductive activation of mitomycin C

1 reference

12 December 2020

A new antitumor antibiotic, FR-900482. II. Production, isolation, characterization and biological activity

1 reference

12 December 2020

Azinomycins A and B, new antitumor antibiotics. I. Producing organism, fermentation, isolation, and characterization

1 reference

12 December 2020

D-glucosamine and L-citrulline, precursors in mitomycin biosynthesis by Streptomyces verticillatus

1 reference

12 December 2020

Homoconjugate addition of organocopper reagents to cyclopropanes and its application to the synthesis of prostanoids

1 reference

12 December 2020

Mitomycin derivatives. 1. Preparation of mitosane and mitosene compounds and their biological activities

1 reference

12 December 2020

Pyrrolo[1,2-a]indole chemistry. Reactions of a tridentate carbanion

1 reference

12 December 2020

A one-step procedure for the preparation of tertiary alpha-ketols from the corresponding ketones

1 reference

12 December 2020

The Mitomyein Antibiotics. Synthetic Studies. V.1 Preparation of 7-Methoxymitosene

1 reference

12 December 2020

The Mitomycin Antibiotics. Synthetic Studies. VII.1 An Exploration of Pyrrolo[1,2-a]indole A-Ring Chemistry Directed toward the Introduction of the Aziridine Function

1 reference

12 December 2020

Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs

1 reference

12 December 2020

New mitomycin, 10-decarbamoyloxy-9-dehydromitomycin B from Streptomyces caespitosus

1 reference

12 December 2020

Maduropeptin: an antitumor chromoprotein with selective protease activity and DNA cleaving properties

1 reference

12 December 2020

Binding of 2,7-diaminomitosene to DNA: model for the precovalent recognition of DNA by activated mitomycin C

1 reference

12 December 2020

Bioactivation as a model for drug design bioreductive alkylation

1 reference

12 December 2020

Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C

1 reference

12 December 2020

Identifiers

DOI

10.3762/BJOC.5.33

1 reference

17 October 2017

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17 October 2017

1 reference

PMCID

2748694