Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells (Q42156460)

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English	Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells	scientific article

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scholarly article

1 reference

Europe PubMed Central

17 October 2017

Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells (English)

1 reference

Europe PubMed Central

17 October 2017

Kenneth C. Anderson

11

object named as

Kenneth C Anderson

1 reference

Europe PubMed Central

17 October 2017

Tanyel Kiziltepe

3

object named as

Tanyel Kiziltepe

1 reference

Europe PubMed Central

17 October 2017

Pierfrancesco Tassone

7

object named as

Pierfrancesco Tassone

1 reference

Europe PubMed Central

17 October 2017

author name string

Laurence Catley

1

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Europe PubMed Central

17 October 2017

Ellen Weisberg

2

1 reference

Europe PubMed Central

17 October 2017

Yu-Tzu Tai

4

1 reference

Europe PubMed Central

17 October 2017

Teru Hideshima

5

1 reference

Europe PubMed Central

17 October 2017

Paola Neri

6

1 reference

Europe PubMed Central

17 October 2017

Peter Atadja

8

1 reference

Europe PubMed Central

17 October 2017

Dharminder Chauhan

9

1 reference

Europe PubMed Central

17 October 2017

Nikhil C Munshi

10

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Europe PubMed Central

17 October 2017

language of work or name

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publication date

25 May 2006

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Europe PubMed Central

17 October 2017

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Europe PubMed Central

17 October 2017

108

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Europe PubMed Central

17 October 2017

10

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Europe PubMed Central

17 October 2017

3441-3449

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Europe PubMed Central

17 October 2017

Antimyeloma activity of heat shock protein-90 inhibition.

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29 May 2018

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895432

29 May 2018

The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895432

29 May 2018

Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895432

29 May 2018

The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895432

29 May 2018

Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895432

29 May 2018

Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications

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29 May 2018

Protein degradation and protection against misfolded or damaged proteins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895432

29 May 2018

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

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29 May 2018

Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895432

29 May 2018

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

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29 May 2018

The Discovery of NVP-LAQ824: From Concept to Clinic

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29 May 2018

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

1 reference

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29 May 2018

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

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29 May 2018

Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.

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29 May 2018

Recent advances in the discovery of small molecule histone deacetylase inhibitors.

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29 May 2018

HDAC6 is a microtubule-associated deacetylase

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29 May 2018

A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator

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29 May 2018

Molecular cloning and characterization of a novel histone deacetylase HDAC10

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29 May 2018

Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways

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29 May 2018

Cloning and characterization of a histone deacetylase, HDAC9

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29 May 2018

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

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29 May 2018

Aggresomes, inclusion bodies and protein aggregation

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29 May 2018

Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

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29 May 2018

Integrin-mediated drug resistance in multiple myeloma

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29 May 2018

Ubiquitin-mediated proteolysis: biological regulation via destruction

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29 May 2018

Retrograde protein translocation: ERADication of secretory proteins in health and disease

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29 May 2018

Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines.

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29 May 2018

Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines

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29 May 2018

Aggresomes: a cellular response to misfolded proteins

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29 May 2018

Protein degradation by the proteasome and dissection of its in vivo importance with synthetic inhibitors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895432

29 May 2018

Structure and functions of the 20S and 26S proteasomes

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29 May 2018

Molecular chaperones in cellular protein folding

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29 May 2018

The ubiquitin-proteasome proteolytic pathway

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29 May 2018

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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29 May 2018

Identity of the 19S 'prosome' particle with the large multifunctional protease complex of mammalian cells (the proteasome).

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29 May 2018

Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma cells and association with drug accumulation and DNA damage.

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29 May 2018

Role of glutathione and its associated enzymes in multidrug-resistant human myeloma cells.

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29 May 2018

Microtubules containing acetylated alpha-tubulin in mammalian cells in culture

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29 May 2018

Monoclonal antibodies specific for an acetylated form of alpha-tubulin recognize the antigen in cilia and flagella from a variety of organisms

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29 May 2018

Glucocorticoid effects on myeloma cells in culture: correlation of growth inhibition with induction of glucocorticoid receptor messenger RNA.

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29 May 2018

Development and characterization of a melphalan-resistant human multiple myeloma cell line

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29 May 2018

A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNA.

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29 May 2018

Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.

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29 May 2018

Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

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17 August 2018

Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells.

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17 August 2018

The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571.

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17 August 2018

NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma

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17 August 2018

Structural Biasing Elements for In-Cell Histone Deacetylase Paralog Selectivity

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17 August 2018

Molecular sequelae of histone deacetylase inhibition in human malignant B cells

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17 August 2018

The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

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17 August 2018

Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition.

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17 August 2018

Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera

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17 August 2018

Direct relation of DNA lesions in multidrug-resistant human myeloma cells to intracellular doxorubicin concentration.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895432

17 August 2018

Involvement of p21(Waf1/Cip1) and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/16728695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16728695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of interleukin 6 in multiple myeloma and bone marrow stromal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16728695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B

1 reference

https://pubmed.ncbi.nlm.nih.gov/16728695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolysis: from the lysosome to ubiquitin and the proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/16728695

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2006-04-016055

1 reference

Europe PubMed Central

17 October 2017

1 reference

Europe PubMed Central

17 October 2017

1 reference

Europe PubMed Central

17 October 2017

ResearchGate publication ID

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