Hematopoietic stem cells and other hematopoietic cells show broad resistance to chemotherapeutic agents in vivo when overexpressing bcl-2. (Q42168728)

17 October 2017

Hematopoietic stem cells and other hematopoietic cells show broad resistance to chemotherapeutic agents in vivo when overexpressing bcl-2. (English)

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17 October 2017

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1 reference

Jos Domen

1

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PubMed ID

12842708

17 October 2017

Irving L Weissman

series ordinal

2

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17 October 2017

1 July 2003

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17 October 2017

Experimental Hematology

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17 October 2017

31

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17 October 2017

7

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17 October 2017

631-639

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Chemotherapy-induced apoptosis

17 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

BCL-2 family: regulators of cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

The Bcl2 family: regulators of the cellular life-or-death switch

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

The biochemistry of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Serine/threonine phosphorylation in cytokine signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Cellular stress response and apoptosis in cancer therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Genetic analysis of chemoresistance in primary murine lymphomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Clinical significance of CD95, Bcl-2 and Bax expression and CD95 function in adult de novo acute myeloid leukemia in context of P-glycoprotein function, maturation stage, and cytogenetics.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Haematopoietic response and bcl-2 expression in patients with acute myeloid leukaemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Pleiotropic drug resistance in B-cell chronic lymphocytic leukaemia--the role of Bcl-2 family dysregulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Drug-induced apoptosis in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

BCL-2 expression does not not correlate with patient outcome in pediatric acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Mutant p53 protein, Bcl-2/Bax ratios and apoptosis in paediatric acute lymphoblastic leukaemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Relationship between nitrogen mustard drug resistance in B-cell chronic lymphocytic leukemia (B-CLL) and protein expression of Bcl-2, Bax, Bcl-X and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

P53, MDM-2, BAX and BCL-2 and drug resistance in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Relevance of p53, bcl-2 and Rb expression on resistance to cisplatin-based chemotherapy in advanced non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Flow cytometric identification of murine neutrophils and monocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Identification of the earliest B lineage stage in mouse bone marrow

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

The c-kit+ maturation pathway in mouse thymic T cell development: lineages and selection

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Simultaneous expression of P-glycoprotein and BCL-2 in acute myeloid leukemia blast cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Synergistic enhancement of resistance to cisplatin in human bladder cancer cells by overexpression of mutant-type p53 and Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Overexpression of Bcl-x(L) promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Bcl-2 mediates chemoresistance in matched pairs of primary E(mu)-myc lymphomas in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Bcl-2 reduces mutant rates in a transgenic lacZ reporter gene in mouse pre-B lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

A novel role for the Bcl-2 protein family: specific suppression of the RAD51 recombination pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

c-kit<low Pluripotent hemopoietic stem cells form CFU-S on day 16

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Oblimersen Bcl-2 antisense: facilitating apoptosis in anticancer treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fate

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2803%2900084-5

7 January 2021

10.1016/S0301-472X(03)00084-5

Identifiers

DOI

1 reference

17 October 2017

1 reference

PubMed ID

12842708